With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125552-89-8,4-(Bromomethyl)tetrahydropyran,as a common compound, the synthetic route is as follows.
5-Bromo-2-oxo-1,2-dihydropyridine-3-carboxylic acid methyl ester (2.3 g, 10 mmol, 1.0 eq) was dissolved in DMF (30 mL), and 4- (bromomethyl) tetramethyl was added Hydrogen-2H-pyran (2.15 g, 12 mmol, 1.2 eq) and potassium carbonate (4.15 g, 30 mmol, 3.0 eq). The mixture was heated to 60 C and stirred for 4 hours. After the reaction was detected by LC-MS and TLC, the temperature was lowered to room temperature, suction filtered, the mother liquor was poured into water (50 mL), and EA (50 mL ¡Á 3) was extracted. The organic phases were combined, washed with saturated brine 3 times, dried, filtered, and concentrated. The crude product was purified by silica gel column chromatography (100-200 mesh silica gel, PE / EA = 0-50%) to obtain an off-white solid (1.8 g, yield: 55%).
125552-89-8, The synthetic route of 125552-89-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Li Lin; Wan Zhonghui; (107 pag.)CN110041316; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics