With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125552-89-8,4-(Bromomethyl)tetrahydropyran,as a common compound, the synthetic route is as follows.
2-({[2-(4-Bromo-2-hydroxyphenyl)ethyl]sulfonyl}amino)-/V-tert-butylbenzenesulfonamide (3.2 g, 6.51 mmol) and 4-(bromomethyl)tetrahydro-2/-/-pyran (3.50 g, 19.54 mmol) were added to a solution of cesium carbonate (6.36 g, 19.54 mmol) in THF (10 mL) and the reaction mixture was heated using MW at 110 C, for 2 h. The reaction mixture was diluted with NH4CI (aq) and extracted with EtOAc two times, washed with water and concentrated. Purification by chromatography on silica using gradient elution of 0-50% EtOAc in n-heptane gave 3.0 g (78 % yield) of the title compound. XH NMR (500 MHz, DMSO-c/6) delta ppm 1.06 – 1.10 (m, 9 H) 1.17 – 1.27 (m, 2 H) 1.53 (br. s., 2 H) 1.81 – 1.92 (m, 1 H) 2.91 – 2.98 (m, 2 H) 3.25 (d, 7=1.58 Hz, 2 H) 3.45 – 3.54 (m, 2 H) 3.77 – 3.85 (m, 4 H) 7.05 (d, 7=1.58 Hz, 1 H) 7.10 – 7.14 (m, 3 H) 7.32 (s, 1 H) 7.59 – 7.70 (m, 3 H) 7.89 (dd, 7=8.04, 1.10 Hz, 1 H) 8.01 (s, 1 H) 8.77 (s, 1 H); MS m/z 589, 590 [M-H]”., 125552-89-8
As the paragraph descriping shows that 125552-89-8 is playing an increasingly important role.
Reference£º
Patent; ACTURUM LIFE SCIENCE AB; SOeDERMAN, Peter; SVENSSON, Mats A; KERS, Annika; OeHBERG, Liselott; HOeGDIN, Katharina; HETTMAN, Andreas; HALLBERG, Jesper; EK, Maria; BYLUND, Johan; NORD, Johan; (0 pag.)WO2016/85392; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics