125552-89-8, 4-(Bromomethyl)tetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of methyl(R)-7-(7-chloro-10-(3-(4-chloro-3,5-dimethy lphenoxy)propy 1)-6-(3,5-dimethy 1-1H-pyrazol-4-y 1)-4-methy l-l-oxo-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-l-methyl-1H-indole-3-carboxylate(20 mg,0. 028mmol) in DMF(0.5 mL) was added NaH(1.4 mg,0.034 mmol) and stirred for 15 min at RT.4-(Bromomethyl)tetrahydro-2H-pyran(5.5 mg,0.031 mmol) was added,and the resultingmixure was stirred overnight then concentrated in vacuo. The residue was purified by flashchromatography(Combi-flash Rf,Hex/EtOAc = 0-70% gradient) to give the title compound(20 mg,88%) as white foam LCMS: RT = 2.107 min,MS(ES) 810.3(M+H).
125552-89-8, 125552-89-8 4-(Bromomethyl)tetrahydropyran 2773286, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; VANDERBILT UNIVERSITY; LEE, Taekyu; TARR, James, C.; JEON, Kyuok; SALOVICH, James, M.; SHAW, Subrata; VEERASAMY, Nagarathanam; KIM, Kwangho; CHRISTOV, Plamen, P.; OLEJNICZAK, Edward, T.; ZHAO, Bin; FESIK, Stephen, W.; BIAN, Zhiguo; (526 pag.)WO2017/152076; (2017); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics