19752-84-2, Tetrahydro-2H-pyran-3-ol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1.48 g of a 57% oil dispersion of sodium hydride was washed with pentane to remove the oil and the sodium hydride was suspended in 10 ml of dimethylformamide. Under a nitrogen atmosphere at 1 C., the suspension was stirred while a solution of 3.00 g of 1A in 15 ml of dimethylformamide was added drop by drop. The mixture was allowed to warm to room temperature and held there for about 1.5 hours, then was cooled to 3-4 C., and a solution of 3.72 g of benzyl chloride in 5 ml of dimethylformamide was added. The mixture was stirred for one hour, then partially stripped of solvent, and the residue was held in a refrigerator overnight. Then most of the solvent was stripped and the residue was stirred in a mixture of equal volumes of water and methylene chloride. The two phases were separated; the aqueous phase was brought to pH 7 with 6 N hydrochloric acid, and extracted with methylene chloride. The organic phases were combined, washed with saturated sodium bicarbonate solution, then with saturated sodium chloride solution, dried (MgSO4) and stripped of solvent. The residue was distilled. 1 was obtained as the fraction boiling at 76 C., 0.1 Torr., 19752-84-2
The synthetic route of 19752-84-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shell Oil Company; US4388104; (1983); A;,
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