65412-03-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.65412-03-5,4-(2-Aminoethyl)tetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.
A solution of D (98 mg, 0.22 mmol) in 1 ,2-dichloroethane (2.0 mL) is added to 214-1 (28 mg, 0.22 mmol). The mixture is shaken overnight. A solution of sodium triacetoxyborohydride (93 mg, 0.44 mmol) in N,N-dimethylacetamide (1.0 mL) is added and the resulting reaction mixture is shaken for 4 hours. Next, the mixture is concentrated and purified by reverse phase HPLC. The desired fractions are pooled and concentrated. The residue is treated with water (1.0 mL) and 1N HCl in Dioxane (58 mu), shaken at 80 C for 2 h, and concentrated. The resultant residue is purified by reverse phase HPLC to give the title product (214).
As the paragraph descriping shows that 65412-03-5 is playing an increasingly important role.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ABEYWARDANE, Asitha; BRUNETTE, Steven Richard; BURKE, Michael Jason; KIRRANE, Thomas Martin, Jr.; MAN, Chuk Chui; MARSHALL, Daniel Richard; PADYANA, Anil Kumar; RAZAVI, Hossein; SIBLEY, Robert; SMITH KEENAN, Lana Louise; SNOW, Roger John; SORCEK, Ronald John; TAKAHASHI, Hidenori; TAYLOR, Steven John; TURNER, Michael Robert; YOUNG, Erick Richard Roush; ZHANG, Qiang; ZHANG, Yunlong; ZINDELL, Renee M.; WO2014/14874; (2014); A1;,
Tetrahydropyran – Wikipedia
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