110238-91-0, Methyl tetrahydro-2H-pyran-4-carboxylate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,110238-91-0
Intermediate 108: Tetrahvdro-2H-pyran-4-ylmethanolMethyl tetrahydro-2H-pyran carboxylate (SC/143233, Aldrich) (5.0 g) in dry THF (10 ml.) was added drop wise to a cooled solution of 1 M lithium aluminium hydride in THF (32 ml_), keeping the temperature below 10 0C. On completion of the addition, the exotherm was allowed to subside before allowing the reaction mixture to warm to room temperature. The reaction was then stirred for 2 hours. The reaction was quenched with water (2 ml.) added very carefully and with cooling, followed by 2N sodium hydroxide (2 ml_). To resultant suspension was then added water (100 ml.) and then extracted with dichloromethane (100 ml_, 3 times). The organic layer was separated, combined and dried by passing through a hydrophobic frit. The organic was evaporated under reduced pressure to give colourless mobile oil that was then placed under high vacuo for 30 minutes at room temperature. This gave the title compound as colourless mobile oil (2.4367 g).1 H NMR (CDCI3): 4.04-3.96 (2H, m), 3.54-3.47 (2H, m), 3.46-3.36 (2H, m), 1.82 – 1.61 (3H, m), 1.57-1.50 (1 H, m), 1.40-1.27 (2H, m)
As the paragraph descriping shows that 110238-91-0 is playing an increasingly important role.
Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/101867; (2008); A1;,
Tetrahydropyran – Wikipedia
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