With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108-55-4,Dihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.
Paclitaxel-2-O-hemiglutarate was prepared according to the method described bySundaram et al. [38]. In brief, paclitaxel (100 mg, 0.117 mM) and glutaric anhydride (13.70 mg,0.12 mM) were dissolved in 15 mL of DCM, and 10 L of dry pyridine was added to the reactionmixture as a base catalyst. The reaction was stirred under nitrogen for 48 h at room temperature.The progress of the reaction was monitored by TLC using hexane:ethyl acetate (7:3, v/v). The crudemixture was purified by silica gel chromatography. The compound was obtained as a white solid(76 mg, 95% yield). HR-MS (ESI) (m/z) [C52H57NO17]: calcd 967.3626; found 968.3479 [M + H]+
108-55-4, 108-55-4 Dihydro-2H-pyran-2,6(3H)-dione 7940, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Article; El-Sayed, Naglaa Salem; Shirazi, Amir Nasrolahi; Sajid, Muhammad Imran; Park, Shang Eun; Parang, Keykavous; Tiwari, Rakesh Kumar; Molecules; vol. 24; 7; (2019);,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics