With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101691-94-5,4-(Iodomethyl)tetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.
A mixture of (6a/?,9a5)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-cyclopent[4,5]imidazo[l,2-alpha]pyrazolo[4,3-e]pyrimidin-4(2H)-one (50 mg, 0.155 mmol), 4-(iodomethyl)-tetrahydro-2H-pyran (70 mg, 0.310 mmol), and Cs2CO3 (101 mg, 0.310 mmol) in DMF (1 mL) is heated in microwave at 140 0C for 30 min. After cooling, the mixture is filtered through a 0.45 mum microflter, and the filtrate is purified by a semi-preparative HPLC to give pure product as white powder. MS (ESI) m/z 421.2 [M+H]+., 101691-94-5
The synthetic route of 101691-94-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; INTRA-CELLULAR THERAPIES, INC.; WO2009/75784; (2009); A1;,
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