With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228779-96-1,3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide,as a common compound, the synthetic route is as follows.
A mixture of2-((1 H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl)methyl)piperazin-1 -yl)benzoic acid (1.75 g, 3 mmol), 3-nitro-4- (((tetrahydro-2H-pyran-4-yl)methyl)am ino)benzenesulfonam ide (1.43 g, 4.5) reacted in EDCI (1.15 g, 6 mmol) and 4-(N,N-dimethylamino)pyridine (550 mg, 4.5 mmol) and dichloromethane (40 ml) at room temperature overnight, and then water was added. The aqueous[2,3-b]pyridin-5-yl)oxy)-4- (4-((6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl)methyl)piperazin-1 -yl)-N-((3-nitr o-4-((tetrahydro-2H-pyran-4-yl)methyl)am ino)phenyl)sulfonyl)benzam ide (1.7 g, 64.4%) was obtained as a yellow solid.1H NMR (400 MHz, methanol-d4) O 8.70 (d, J = 2.3 Hz,1 H), 8.01 (d, J =2.7 Hz, 1 H), 7.87 (d, J = 9.2, 2.3 Hz, 1 H), 7.66 (d, J = 8.9 Hz, 1 H),7.55 (d, J =2.7 Hz, 1H), 7.47 (d, J = 3.4 Hz, 1H), 7.38 (d, J = 8.4 Hz, 2H), 7.10 (d, J =8.4Hz, 2H), 6.97 (d, J = 9.2 Hz, 1 H), 6.77 (dd, J = 8.9, 2.4 Hz, 1 H), 6.44 (d, J =3.4Hz, 1 H), 6.34 (d, J = 2.4 Hz, 1 H), 4.02 – 3.94 (m, 3H), 3.66 (5, 3H), 3.49 -3.38 (m,2H), 3.41 – 3.25 (m, 7H), 2.42 (5, 3H), 2.26 (5, 3H), 2.00 – 1.67 (m, 4H),1.45- 1.38(m, 2H)., 1228779-96-1
1228779-96-1 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide 57474953, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; ASCENTAGE PHARMA (SUZHOU) CO., LTD.; YANG, Dajun; ZHAI, Yifan; WANG, Guangfeng; (88 pag.)WO2020/24826; (2020); A1;,
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