With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23462-75-1,Dihydro-2H-pyran-3(4H)-one,as a common compound, the synthetic route is as follows.
Dihydro-2//-pyran-3(4H)-one (100 mg, 1.00 mmol), /er/-butyl carbazate (145 mg, 1.10 mmol, Ll equiv) and acetic acid (0.280 niL, 4.99 mmol, 5 equiv) were combined in 1 ,2-dichloroethane(3 raL), stirred at ambient temperature for 10 minutes and treated with sodium triacetoxyborohydride (296 mg, 1,34 mmol, 1.4 equiv). After stirring for 1 hour, the mixture was poured into water and extracted with ethyl acetate (3 x 50 niL), The combined organic extracts were dried with sodium sulfate, filtered and concentrated in vacuo to provide the titled compound., 23462-75-1
23462-75-1 Dihydro-2H-pyran-3(4H)-one 90109, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK SHARP &; DOHME CORP.; BESHORE, Douglas, C.; KUDUK, Scott, D.; WO2010/123716; (2010); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics