With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228779-96-1,3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide,as a common compound, the synthetic route is as follows.
In a 500mL reaction flask, add intermediate V4 (24.5g, 32mmol, 1.0eq), intermediate VM4 (13g, 41mmol, 1.3eq) and 800mL dichloromethane, stir to dissolve, then add CDI (7.7g, 48mmol, 1.5eq ) And 2.5g DMAP, heated to 30-35 reaction,TLC monitors the reaction.After the reaction is completed, add 300mL of 10% acetic acid aqueous solution and stir for 30min to separate the organic phase.The organic phase was washed with saturated aqueous sodium bicarbonate solution (200 mL ¡Á 1) and saturated aqueous sodium chloride solution (200 mL ¡Á 1), dried over anhydrous sodium sulfate, filtered with suction, and the filtrate was concentrated under reduced pressure to obtain a crude solid product. The crude product was recrystallized with 300 mL of ethyl acetate and n-hexane (1: 1),29.2 g of solid product V5 was obtained.Yield: 87%.
1228779-96-1, As the paragraph descriping shows that 1228779-96-1 is playing an increasingly important role.
Reference£º
Patent; Nantong Changyou Pharmaceutical Technology Co., Ltd.; Li Zebiao; Chen Dan; Wu Hongdang; Xu Xiaohong; Lin Yanfeng; (9 pag.)CN110878098; (2020); A;,
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