40191-32-0, Tetrahydro-2H-pyran-4-carbonyl chloride is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Sodium carbonate (15 mg, 0.14 mmol) and tetrahydro-2H-pyran-4-carbonyl chloride (26 mg, 0.18 mmol) were added to mixture of 5-amino-1-(4-chlorobenzyl)-2-(methylthio)pyrimidin-6(1H)-one (33.2 mg, 0.118 mmol) and THF (0.5 mL) under ice-cooling, and stirred under ice-cooling for 2 hours. The reaction mixture was added to saturated sodium hydrogen carbonate aqueous solution, and extracted with ethyl acetate. The extract was washed by saturated saline, dried over anhydrous sodium sulfate, and then concentrated in vacuo to give 3-(4-chlorobenzyl)-2-methylthio-5-(tetrahydro-2H-pyran-4-ylcarbonylamino)pyrimidin-6(1H)-one (48 mg, yield: 100%) as pale yellow solid. 1H-NMR (delta ppm TMS/DMSO-d6): 1.54-1.70 (4H, m), 2.50 (3H, s), 2.83-2.92 (1H, m), 3.27-3.35 (2H, m), 3.84-3.91 (2H, m), 5.25 (2H, s), 7.27 (2H, d, J=7.8 Hz), 7.41 (2H, d, J=7.8 Hz), 8.70 (1H, s), 9.31 (1H, s).
40191-32-0, As the paragraph descriping shows that 40191-32-0 is playing an increasingly important role.
Reference£º
Patent; Shionogi & Co., Ltd.; KAI, Hiroyuki; TANAKA, Satoru; HIRAMATSU, Yoshiharu; NOZU, Azusa; NAKAMURA, Ken’ichioh; (260 pag.)US2016/24072; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics