With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19752-84-2,Tetrahydro-2H-pyran-3-ol,as a common compound, the synthetic route is as follows.
Preparation 27; 4-Bromo-2-((tetrahydro-2H-pyran-3-yl)oxy)pyridine To a solution of tetrahydro-2H-pyran-3-ol (0.10 g, 0.97 mmol) in THF (2.5 mL) was added sodium hydride (60% dispersion in mineral oil, 0.065 g, 1.6 mmol) and stirred at ambient temperature for about 2 h. To the reaction mixture was added 4-bromo-2-fluoropyridine (0.144 g, 0.816 mmol) in THF (2.5 mL). After about 16 h, water (5 mL) and EtOAc (10 mL) were added. The organic layer was separated and the aqueous layer was back extracted with EtOAc (10 mL). The combined organic layers were dried over MgS04, filtered and concentrated under reduced pressure. The material was purified via flash chromatography on silica gel (0-50% EtOAc/heptane). The appropriate fractions were collected and concentrated under reduced pressure to provide the title product (0.1 17 g, 55%); LC/MS (Table A, Method i) = 1.33 min.; MS m/z: 258 and 260 (M+H) ., 19752-84-2
The synthetic route of 19752-84-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ABBVIE INC.; ARGIRIADI, Maria; BREINLINGER, Eric; DIETRICH, Justin, D.; FRIEDMAN, Michael; IHLE, David; MORYTKO, Michael; MULLEN, Kelly; OSUMA, Augustine; LO SCHIAVO, Gloria, Y.; WILSON, Noel, S.; (303 pag.)WO2016/168633; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics