With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25637-16-5,4-Bromotetrahydropyran,as a common compound, the synthetic route is as follows.
General procedure: Sodium hydride (60% suspension in mineral oil, 31 mg, 0,76 mmol) is added to asolution of 36a (109 mg, 91 % content, 0,63 mmol) in DMF (1 mL) at 0C. After 20mi 2-(trimethylsilyl)ethoxymethyl chloride (157 p1, 0,88 mmol) is added dropwise tothe reaction mixture. After stirring for 1 h at rt, the reaction is diluted with EtOAc,washed with NaHCO3 satured solution and brine. The organic layer is separated and dried with a Phase separator cartridge and evaporated under vacuum to give a residue that is purified by flash chromatography (eluent 0-10% EtOAc/cyclohexane) to furnish the title compound (182 mg).UPLC-MS (Method 2): Rt = 1 .61MS (ESI pos): mlz = 288 (M+H)+
25637-16-5, 25637-16-5 4-Bromotetrahydropyran 13349654, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GIOVANNINI, Riccardo; CUI, Yunhai; DOODS, Henri; FERRARA, Marco; JUST, Stefan; KUELZER, Raimund; LINGARD, Iain; MAZZAFERRO, Rocco; RUDOLF, Klaus; WO2014/184275; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics