951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
951127-25-6, tert-Butyl N-[(2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydropyran-3-yl]carboxylate(0.22 g, 0.67 mmol) was dissolved in N,N-dimethylacetamide (3.3 mL).Add 2-(2-thienylsulfonyl)-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole 4-methylbenzenesulfonate (0.38 g, 0.89 mmol) at room temperature 10 minutes, nitrogen protection,Sodium triacetoxyborohydride (0.83 g, 3.93 mmol) was slowly added at 0 C.The reaction was resumed at room temperature for 12 hours.The reaction was quenched by the addition of aqueous ammonia/water (v/v = 2/3, 50 mL) and filtered.The obtained solid was purified by silica gel column chromatography [methanol / dichloromethane (v / v) = 1 / 9]The title compound was obtained (0.30 g, yield 79%).It is a brown foamy solid.
The synthetic route of 951127-25-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ruyuan Yong Xing Technology Services Co., Ltd.; Li Jianhao; Gu Zheng; Deng Xinshan; Tang Wanjun; Zhang Zongyuan; Kang Panpan; Yuan Weihui; Peng Fei; (49 pag.)CN109942583; (2019); A;,
Tetrahydropyran – Wikipedia
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