951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,951127-25-6
2.46 kg of Compound III and 3.12 kg of Compound II were added to 15 L of N, N-dimethylacetamide, and nitrogenUnder guard,Circulating frozen saline bath to 5 ¡À 5 ,Added dropwise trimethyl orthoformate 2.2Kg,Sodium borohydride acetate was added in portions3.19Kg,Stirred at 5 ¡À 5 C for 2 hours,Heated to 50 ¡À 5 for about 10 hours;Circulating frozen saline bath to 5 ¡À 5 ,45 C below the drop in water 15L,Add Bi temperature at this temperature for 1 hour,Heated to 50 ¡À 5 C for 2 hours,Centrifuge,Wet product washed with water 5L three times,Wet product was added to the water 15L beating 1 hour,Centrifuge,50 C for 12 hours under vacuum.Get gray whiteSolid was added isopropyl ether 12L,Heated to 60 ¡À 5 ,Then add n-heptane 12L, cooled to 15 ¡À 5 , incubated for 1 hour,Suction filtered and dried under vacuum at 40 C for 12 hours to obtain 3.1Kg of white solid with a yield of 82.5%
As the paragraph descriping shows that 951127-25-6 is playing an increasingly important role.
Reference£º
Patent; Shanghai Bozhi Yan Xin Pharmaceutical Co., Ltd.; Ying Shuhuan; Pi Hongjun; Chen Jian; (14 pag.)CN106674227; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics