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4-OXO-3,5,7,8-TETRAHYDRO-4H-PYRANO {4,3-D} PYRMINIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS

The present invention provides for compounds of formula (I) wherein R1 and R2 are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer

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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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74808-09-6, Name is (2R,3R,4S,5R,6R)-3,4,5-Tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl 2,2,2-trichloroacetimidate, molecular formula is C36H36Cl3NO6, belongs to Tetrahydropyrans compound, is a common compound. In a patnet, once mentioned the new application about 74808-09-6, Recommanded Product: 74808-09-6

A mild ligand-free iron-catalyzed liberation of alcohols from allylcarbonates

Different from most carbonates the allyloxy carbonyl protecting group can be cleaved under neutral conditions using metal catalysis. However, most of the catalysts employed to date are based upon precious metals. Herein we present two protocols for the mild Fe-catalyzed liberation of alcohols from allylcarbonates that are characterized by broad functional group tolerance and exclusive chemoselectivity.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Properties and Exciting Facts About 499-40-1

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal. In my other articles, you can also check out more blogs about 499-40-1

499-40-1, Name is (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal, molecular formula is C12H22O11, belongs to Tetrahydropyrans compound, is a common compound. In a patnet, once mentioned the new application about 499-40-1, Application In Synthesis of (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal

Containing 2, 2′ – dipyridylamine of BODIPY-based fluorescent probe and its synthetic method and application (by machine translation)

Design of this invention is to synthesize a compound of formula (N1) is shown containing 2, 2′ – dipyridylamine of BODIPY-based fluorescent probe, and its application to metal ion detection, for the purposes of its detection effect, compared with the many quenching fluorescence probe, the fluorescent probe belongs to the enhanced fluorescent probe, has higher sensitivity, in addition achieves the multi-metal ion the effective detection of, improves the efficiency and utilization of the probe. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal. In my other articles, you can also check out more blogs about 499-40-1

Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Discovery of 61363-56-2

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Related Products of 61363-56-2. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 61363-56-2, Name is 2H-Pyran-3,5(4H,6H)-dione. In a document type is Article, introducing its new discovery.

On the Mechanism of Graham’s Reaction

The oxidative cyclization of amidines to 3-chloro-3-substituted diazirines with aqueous sodium hypochlorite proceeds through N-chloro- and N,N’-dichloroamidines; the latter are isolable in certain cases.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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Related Products of 14215-68-0, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 14215-68-0, Name is N-((2S,3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide, molecular formula is C8H15NO6. In a Article£¬once mentioned of 14215-68-0

Sugar binding effects on the enzymatic reaction and conformation near the active site of pokeweed antiviral protein revealed by fluorescence spectroscopy

In various trials for elucidating the physiological function of pokeweed antiviral protein (PAP), studies on the interaction with sugar are essential. The fluorescence titration curves showed that PAP retained the strong affinity against N-acetylglucosamine (NAG) and two sites in one PAP molecule co-operatively participated in the binding. In the complex of PAP with NAG, Trp208 located at the entrance lid site of substrate came closer to Tyr72 about 0.3 A. Furthermore, the fluorescence anisotropy decay measurement demonstrated that the segmental rotation of Trp208 was enlarged by the binding of PAP with NAG. Such conformational changes around the active site closely correlate with the enzymatic activity of PAP. The N-glycosidase activity of PAP was enhanced more than two times in the presence of NAG. The obtained results consistently suggested the enzymatic activity of PAP would be regulated through the conformation change near the active site induced by the binding with NAG.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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Reference of 134419-59-3, An article , which mentions 134419-59-3, molecular formula is C6H12O4S. The compound – Tetrahydro-2H-pyran-4-yl methanesulfonate played an important role in people’s production and life.

5, 7-SUBSTITUTED-IMDAZO [1, 2-C] PYRIMIDINES AS INHIBITORS OF JAK KINASES

Compounds of Formula I: (Formula should be inserted here) and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3, R4, R5, R6, R7, X1 and X2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities

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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: Tetrahydropyran-4-carbaldehyde. In my other articles, you can also check out more blogs about 50675-18-8

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 50675-18-8, Name is Tetrahydropyran-4-carbaldehyde, molecular formula is C6H10O2. In a Patent£¬once mentioned of 50675-18-8, Quality Control of: Tetrahydropyran-4-carbaldehyde

Multi-substituted indazoles compounds and their use as inhibitors of IDO (by machine translation)

The invention discloses a compound of formula (I) as shown by the multi-substituted indazoles compounds, also discloses the preparation of the compounds and as the use of the IDO inhibitor. The compounds of this invention can be used for the prevention and/or the treatment of various diseases, such as Alzheimer’s disease, cataracts, cell immune activation-related infection, autoimmune disease, aids, cancer, such as depression or tryptophan metabolic abnormalities. (by machine translation)

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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METABOLITES OF CERTAIN [1,4]DIAZEPINO[6,7,1-IJ]QUINOLINE DERIVATIVES AND METHODS OF PREPARATION AND USE THEREOF

The invention relates to metabolites of certain [1,4]diazepino[6,7,1-i~]quinoline derivatives and methods of preparation and use thereof. Specifically, the invention relates to compounds of formula I wherein the various substituents are defined herein. The invention also provides pharmaceutical compositions including compounds of formula I, methods of making such compounds, and methods of using such compounds.

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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

A new application about 499-40-1

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Formula: C12H22O11. In my other articles, you can also check out more blogs about 499-40-1

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 499-40-1, Name is (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal, molecular formula is C12H22O11. In a Article£¬once mentioned of 499-40-1, Formula: C12H22O11

The coordination chemistry of dinitrato-di-2-pyridylamine copper(II). Crystal structures of catena-poly[[(di-2- pyridylamine)(nitrato-O,O?)copper(ii)]-mu-nitrato-O:O?] and bis(nitrato-O,O?)(di-2-pyridylamine)copper(II) dihydrate

The preparation, characterization and crystal structures of the mono(dpyam) copper(II)nitrato complexes [Cu(dpyam)(O2NO)2] (1) and [Cu(dpyam)(O2NO)2]¡¤2H2O (2) (dpyam = di-2-pyridylamine) have been investigated. Compound 1 consists of two crystallographically independent [Cu(dpyam)(O2NO)2] neutral molecules. These molecules are linked into infinite chains by the bridging bidentate nitrate groups in the long-bonded tetragonal positions giving an elongated rhombic octahedral stereochemistry. The structure of 2 is composed of a couple of crystallographically independent [Cu(dpyam)(O2NO)2] neutral molecules and four water molecules in the lattice. Each copper atom exhibits a tetrahedrally distorted square base of the N2O2 plane, with the second oxygen atoms of the monodentate nitrato groups weakly bound in nearly axial positions giving an extremely distorted octahedral coordination geometry.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 40191-32-0 is helpful to your research., Recommanded Product: Tetrahydro-2H-pyran-4-carbonyl chloride

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.40191-32-0, Name is Tetrahydro-2H-pyran-4-carbonyl chloride, molecular formula is C6H9ClO2. In a Patent£¬once mentioned of 40191-32-0, Recommanded Product: Tetrahydro-2H-pyran-4-carbonyl chloride

IMIDAZOPYRAZINONES AS PDE1 INHIBITORS

The present invention provides imidazopyrazinones as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics