Discovery of tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate

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Stereoselective and Regioselective Preparation of C-Pentopyranosides and Formal Synthesis of Omarigliptin

A readily available intermediate obtained from d-arabinose was identified as a versatile starting material for the stereoselective synthesis of C-pentopyranosides in one pot. For two of the C-pentopyranosides, subsequent epoxide ring formation and a regioselective opening process was proven to be a robust approach to 3-deoxy C-pentopyranosides in two to four steps. A key intermediate used in the preparation of omarigliptin was obtained in four steps. Most of the conversions were high-yielding and proceeded with high selectivities on a multigram scale.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

New explortion of 388109-26-0

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Synthetic Route of 388109-26-0, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 388109-26-0, Name is Ethyl 3-oxotetrahydro-2H-pyran-4-carboxylate, molecular formula is C8H12O4. In a Patent£¬once mentioned of 388109-26-0

FUSED IMIDAZOLE DERIVATIVES AS IL-17 MODULATORS

A series of substituted fused bicyclic imidazole derivatives, including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

New explortion of Tetrahydropyran-4-carbaldehyde

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Discovery and structure-activity relationships of spiroindolines as novel inducers of oligodendrocyte progenitor cell differentiation

A novel series of spiroindoline derivatives was discovered for use as inducers of oligodendrocyte progenitor cell (OPC) differentiation, resulting from optimization of screening hit 1. Exploration of structure-activity relationships led to compound 18, which showed improved potency (rOPC EC50 = 0.0032 muM). Furthermore, oral administration of compound 18 significantly decreased clinical severity in an experimental autoimmune encephalomyelitis (EAE) model.

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Tetrahydropyran – Wikipedia,
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More research is needed about 2081-44-9

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Application of 2081-44-9, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 2081-44-9, Name is Tetrahydro-2H-pyran-4-ol, molecular formula is C5H10O2. In a Patent£¬once mentioned of 2081-44-9

NITROGEN-CONTAINING HETEROCYCLIC COMPOUND

The present invention provides a novel compound having a superior activity as an ERR-alpha modulator and useful as an agent for the prophylaxis or treatment of ERR-alpha associated diseases. The present invention relates to a compound represented by the formula (1) wherein each symbol is as defined in the specification, or a salt thereof

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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The important role of (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal

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Reference of 499-40-1, An article , which mentions 499-40-1, molecular formula is C12H22O11. The compound – (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal played an important role in people’s production and life.

D-tartaric acid 2,2-bipyridine amine cobalt ferroelectric functional material and its preparation method (by machine translation)

The invention discloses a D-tartaric acid 2,2-dipyridylamine cobalt ferroelectric function material and a preparation method. The molecular formula is [Co(dpa)(D-C4H4O6)]2.8H2O, wherein dpa is 2,2-dipyridylamine; the ferroelectric function material is monoclinic system powder of which the purity is not lower than 99%; the structure of space group is C2; the ferroelectric characteristic parameters are as follows: the remanent polarization strength 2Pr=0.05(mu)C.cm<-2>, coercive electric field 2Ec=15.2kv.cm<-1>, and saturization polarization strength Ps=0.249(mu)c.cm<-2>; and the ferroelectric function material has relatively good ferroelectric characteristics. The preparation method of the ferroelectric function material comprises the following steps of: enabling the newly prepared cobalt carbonate to react with the mixed solution of D-tartaric acid 2,2-dipyridylamine to obtain a D-tartaric acid 2,2-dipyridylamine cobalt solution; devitrifying; and grinding to obtain ferroelectric function material powder passing through a 100-mesh sieve. The method has the advantages of few processes, simple technology, low requirements on equipment, cheap materials of cobalt salt and tartaric acid, no pollution, low cost and easiness in realizing industrialization.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Can You Really Do Chemisty Experiments About 499-40-1

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 499-40-1, Name is (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal, molecular formula is C12H22O11. In a Article£¬once mentioned of 499-40-1, category: Tetrahydropyrans

A rare earth alloy as a synthetic reagent: Contrasting homometallic rare earth and heterobimetallic outcomes

Reaction of LaNi5 with 2,2?-dipyridylamine (HNpy 2) at 170C under vacuum gave crystals of dimeric [La(Npy 2)3]2 as a previously unknown eight-coordinate isomer (1a) (two mu-eta2:eta2 and two terminal chelating (Namide,Npy) Npy2 ligands), which reverts to the known ten coordinate isomer (1b) on recrystallisation from THF/PhMe, thereby establishing linkage isomerism of a [Ln(Npy2) 3]2 complex for the first time. Reaction of 8-hydroxyquinoline (HOQ) with excess LaNi5 alloy at 190C resulted in extraction of both metals and the formation of heterobimetallic [Ni2La(OQ)7] (2). The trinuclear complex has two terminal, fac-octahedral nickel(II) sites, each bound to three chelating 8-quinolinolate anions which bridge through the oxygen atoms to the lanthanum(III) centre. The eight-coordinate lanthanum environment is completed by a chelating OQ ligand. the Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2006.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Awesome Chemistry Experiments For 14215-68-0

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A 1-acetamido derivative of 6-epi-valienamine: An inhibitor of a diverse group of beta-N-acetylglucosaminidases

The synthesis of an analogue of 6-epi-valienamine bearing an acetamido group and its characterisation as an inhibitor of beta-N- acetylglucosaminidases are described. The compound is a good inhibitor of both human O-GlcNAcase and human beta-hexosaminidase, as well as two bacterial beta-N-acetylglucosaminidases. A 3-D structure of the complex of Bacteroides thetaiotaomicron BtGH84 with the inhibitor shows the unsaturated ring is surprisingly distorted away from its favoured solution phase conformation and reveals potential for improved inhibitor potency. This journal is The Royal Society of Chemistry.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The Absolute Best Science Experiment for 50675-18-8

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Novel benzimidazole derivatives as selective CB2 agonists

The preparation and evaluation of a novel class of CB2 agonists based on a benzimidazole moiety are reported. They showed binding affinities up to 1 nM towards the CB2 receptor with partial to full agonist potencies. They also demonstrated good to excellent selectivity (>1000-fold) over the CB1 receptor.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Top Picks: new discover of (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal

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CATION DISTORTION ISOMERISM IN THREE FIVE-CO-ORDINATE DIETHYLENETRIAMINE(DI-2-PYRIDYLAMINE)COPPER(II) COMPLEXES

The crystal structures of three X2*nH2O (dien = diethylenetriamine, bipyam = di-2-pyridylamine) complexes have been determined by R-ray crystallographic methods, where X = Cl(1-), n = 2 (1); X = ClO4(1-), n = 1 (2); X = NO3(1-), n = 0 (3).All three crystallise in the monoclinic, space group P21/c with Z = 4; in (1) a = 7.78(2), b = 9.75(3), c = 28.01(5) Angstroem, and beta = 115.0(5) deg; in (2) a = 15.683(5), b = 7.621(5), c = 21.044(9) Angstroem, and beta = 121.42(2) deg; and in (3) a = 12.2011(5), b = 16.052(6), c = 9.851(4) Angstroem, and beta = 90.76(2) deg.All three structures were solved by heavy-atom techniques and successive Fourier syntheses; all three complexes involve a distorted five-co-ordinate CuN5 chromophore, whose stereochemistry ranges from distorted square pyramidal in (1), through an intermediate geometry in (2), to a distorted trigonal-bipyramidal stereochemistry in (3).The three stereochemistries represent individual structures in the pathway of the Berry twist and represent cation distortion isomers of the (2+) cation.The angular changes in the CuN5 stereochemistry are paralelled in the electronic reflectance spectra of the three complexes and in the calculated crystal-field energy level of the copper(II) ion.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

More research is needed about 2081-44-9

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HETEROARYL COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF

The present invention provides herein is a heteroaryl compound or a stereoisomer, a geometric isomer, a tautomer, a racemate, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, as well as a pharmaceutical composition containing the compound disclosed herein. The present invention also provides herein is use of the compound or the pharmaceutical composition thereof disclosed herein in the manufacture of a medicine for treating autoimmune diseases or proliferative diseases.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics