The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.5631-96-9, Name is 2-(2-Chloroethoxy)tetrahydro-2H-pyran, molecular formula is C7H13ClO2. In a Article£¬once mentioned of 5631-96-9, SDS of cas: 5631-96-9
Acid-Catalyzed Hydrolyses of 2-Alkoxytetrahydropyrans: Evidence for the Changeover from an A1 to an ASE2 Mechanism
Kinetics of the acid-catalyzed hydrolyses of 2-ethoxy-, 2-methoxy-, 2-(2-methoxyethoxy)-, 2-(2-chloroethoxy)-, 2-(propargyloxy)-, and 2-(2,2,2-trifluoroethoxy)tetrahydropyran have been studied in aqueous acidic solutions.The hydrolysis of 2-(2,2,2-trifluoroethoxy)tetrahydropyran occurs by an ASE2 mechanism and exhibits the requisite general acid catalysis.While this mechanism cannot be strictly excluded for the hydrolysis of 2-ethoxytetrahydropyran, the lack of observation of general acid catalysis and the manner in which enthalpies and entropies of activation change as the 2-alkoxy group is changed strongly suggest an A1 mechanism.A rationale is presented for using entropies of activation as an indication of changeover from an A1 to an ASE2 mechanism, based on the tetrahydropyran series (where such a changeover appears to occur) and on the benzaldehyde series (where hydrolyses occur by an ASE2-like mechanism).It is observed that in order for a physical organic model to closely resemble the hydrolysis of a natural substrate at the active site of an enzyme (e.g., lysozyme), the leaving group must contain electronegative groups: aryloxy, 2,2,2-trifluoroethoxy, and 2-propargyloxy all seem adequate.This structural feature is much more important than inherent reactivity; thus 2-(2,2,2-trifluoroethoxy)tetrahydropyran is a better reaction model than methyl glucosides.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.SDS of cas: 5631-96-9, you can also check out more blogs about5631-96-9
Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics