The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.125995-03-1, Name is Atorvastatin lactone, molecular formula is C33H33FN2O4. In a Article£¬once mentioned of 125995-03-1, Safety of Atorvastatin lactone
LC-MS/MS method for quantification of atorvastatin, o-hydroxyatorvastatin, p-hydroxyatorvastatin, and atorvastatin lactone in rat plasma
A simple and sensitive liquid chromatography-tandem mass spectrometry method was developed for the quantification of atorvastatin, ortho-hydroxyatorvastatin, para-hydroxyatorvastatin, and atorvastatin lactone in rat plasma. Solid-phase extraction was used for preparation of samples. Rosuvastatin was chosen as an internal standard. Chromatographic separation was achieved on ZORBAX Eclipse C18 Analytical, 4.6 ¡Á 100 mm (3.5 mum) column with a gradient mobile phase composed of acetonitrile and 0.1% acetic acid, at a flow rate of 400 muL min-1. The column was kept at constant temperature (25 C), and autosampler tray temperature was set at 4 C. The following selected reaction monitoring (SRM) transitions were selected: (m/z, Q1 ? Q3, collision energy) atorvastatin (559.47 ? 440.03, 22 eV), atorvastatin lactone (541.36 ? 448.02, 19 eV), orthohydroxyatorvastatin (575.20 ? 440.18, 20 eV), para-hydroxyatorvastatin (575.54 ? 440.18, 20 eV), and rosuvastatin (482.25 with selected combination of two fragments 257.77, 31 eV, and 299.81, 35 eV) in positive ion mode. The method was validated over a concentration range of 0.5-20 ng mL-1 for ortho-hydroxyatorvastatin and para-hydroxyatorvastatin and 0.1-20 ng mL-1 for atorvastatin and atorvastatin lactone with excellent linearity (r2 = 0.99). This method demonstrated acceptable precision and accuracy at four quality control concentration levels. The detection limits were 0.1 and 0.13 ng mL-1 for orthohydroxyatorvastatin and para-hydroxyatorvastatin, respectively, and 0.05 ng mL-1 for atorvastatin and atorvastatin lactone. All analytes were found to be stable at examined conditions. Validated method was applied for determination of atorvastatin and its metabolites in plasma of experimental animals.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Safety of Atorvastatin lactone, you can also check out more blogs about125995-03-1
Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics