In an article, published in an article, once mentioned the application of 2081-44-9, Name is Tetrahydro-2H-pyran-4-ol,molecular formula is C5H10O2, is a conventional compound. this article was the specific content is as follows.COA of Formula: C5H10O2
SALT OF, AND PROCESSES FOR THE PREPARATION OF, 1-ISOPROPYL-4-{[4-(TETRAHYDRO-2H-PYRAN- 4-YLOXY)PHENYL]CARBONYL}HEXAHYDRO-1H-1,4-DIAZEPINE
The invention relates to 1-isopropyl-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}hexahydro-1H-1,4-diazepine mono-maleate, and crystalline Form 1 thereof. The invention also provides a process for the preparation of 1-isopropyl-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}hexahydro-1H-1,4-diazepine (Formula (A)) or a pharmaceutically acceptable salt thereof, which process comprises: (a) reacting a non-acid-chloride derivative of 4-(tetrahydro-2H-pyran-4-yloxy)benzoic acid, in which the carboxylic acid group has been activated, with 1-isopropyl-hexahydro-1H-1,4-diazepine; and (b) optionally preparing a pharmaceutically acceptable salt of 1-isopropyl-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}hexahydro-1H-1,4-diazepine. Process (a) typically comprises activation of 4-(tetrahydro-2H-pyran-4-yloxy)benzoic acid with a coupling reagent, preferably carbonyl diimidazole, followed by reaction with 1-isopropyl-hexahydro-1H-1,4-diazepine. The invention also provides 1-isopropyl-hexahydro-1H-1,4-diazepine bis-trifluoroacetate. The invention also provides a process for preparing a compound of formula (III) wherein P represents a protecting group.
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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics