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Glucosamine analogues are inhibitors of yeast hexokinase (HK); kinetic analysis with respect to glucose and ATP suggests a pseudo-substrate behaviour for these compounds. However, a spectroscopy study by 31P NMR indicates that they are not phosphorylated but that, in fact, they enhance the ATPase activity of HK; this result gives a further insight into the phosphorylation or ATP hydrolysis process in HK.
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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics