The Absolute Best Science Experiment for (2S,3S,4S,5R,6R)-2-(Methoxycarbonyl)-6-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate

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Convenient syntheses of metabolically important quercetin glucuronides and sulfates

Synthetic approaches to the major human plasma metabolites of quercetin, quercetin 3?-sulfate and the beta-d-glucopyranosiduronic acid derivatives 3?-methylquercetin 3-glucuronide (isorhamnetin 3-glucuronide), quercetin 3-glucuronide and quercetin 3?-glucuronide are described. This is the first report of the chemical synthesis of quercetin 3?-glucuronide. All procedures start from the same precursor, 4?,7-di-O-benzylquercetin, and all are more convenient than existing methods.

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics