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We designed and synthesized a series of 2-Ar-8-methyl-5- alkylaminolquinolines as potent corticotropin-releasing factor 1 (CRF 1) receptor antagonists. The structure-activity relationships of substituents at each position (R3, R5, R 5?, and R8) was investigated. By derivatization, three compounds (6, 14b, and 14c) were identified as orally active CRF 1 receptor antagonists.
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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics