Synthetic Route of 233276-38-5. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 233276-38-5, Name is 4-Methyltetrahydro-2H-pyran-4-carboxylic acid. In a document type is Article, introducing its new discovery.
The direct union of primary, secondary, and tertiary carboxylic acids with a chiral glyoxylate-derived sulfinimine provides rapid access into a variety of enantiomerically pure alpha-amino acids (>85 examples). Characterized by operational simplicity, this radical-based reaction enables the modular assembly of exotic alpha-amino acids, including both unprecedented structures and those of established industrial value. The described method performs well in high-throughput library synthesis, and has already been implemented in three distinct medicinal chemistry campaigns.
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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics