Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 31608-22-7, Name is 2-(4-Bromobutoxy)tetrahydro-2H-pyran, Safety of 2-(4-Bromobutoxy)tetrahydro-2H-pyran.
The first total synthesis for the novel fatty acid (±)-2-methoxy-6- icosynoic acid was accomplished in seven steps and in a 14% overall yield starting from 2-(4-bromobutoxy)-tetrahydro-2H-pyran. The title compound displayed an EC50 = 23 ± 1 muM against the human SH-SY5Y neuroblastoma cell line and an EC50 = 26 ± 1 muM against the human adenocarcinoma cervix cell line (HeLa) after 48 h of exposure. The corresponding non-methoxylated analog 6-icosynoic acid did not display cytotoxicity (EC50 > 500 muM) toward the studied cell lines as well as the 2-methoxyicosanoic acid (EC50 > 300 muM). The critical micelle concentration (CMC = 20-30 muM) for the (±)-2-methoxy-6-icosynoic acid was also determined. It was found that mu-methoxylation decreases the CMC of a fatty acid.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Safety of 2-(4-Bromobutoxy)tetrahydro-2H-pyran. In my other articles, you can also check out more blogs about 31608-22-7
Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics