Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. 125995-03-1, Name is Atorvastatin lactone, molecular formula is C33H33FN2O4. In a Article，once mentioned of 125995-03-1, Electric Literature of 125995-03-1
Background: The most effective method of lowering cholesterol is the administration of statins. Cholesterol-lowing effects of statin may be affected by polymorphisms of detoxification genes. Methodology: In this study, 130 adult patients suffering from hypercholesterolemia and receiving atorvastatin therapy (40 mg daily) were enrolled. At 12-15 months subsequent to treatment of atorvastatin, Total Cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and genes of cytochrome P450 (CYP) 3A4, UDP-glucuronosyltransferase (UGT) 1A1, UGT1A3, multidrug resistance proteins 1 (MDR1) and organic anion transporter polypeptides 2 (OATP2) in the study subjects were determined. Results: There were 87 and 43 subjects whose TC concentrations were <5.1 and ?5.1 mmol L?1, respectively and 93 and 37 patients whose LDL-C concentrations were <3.3 and ?3.3 mmol L?1, respectively. Odds Ratio (OR) of wild type in the UGT1A1 gene was 0.389 (95% confidence interval = 0.174-0.873, p = 0.02) in the subjects whose TC concentrations were compared between <5.1 and ?5.1 mmol L?1, while ORs of other haplotypes in the UGT1A1 gene (OR = 0.976-1.464, p = 0.37-0.98) and haplotypes of CYP3A4, UGT1A3, MDR1 and OATP2 genes (OR = 0.561-3.818, p = 0.14-0.99) were not statistically significant. For LDL-C concentrations, ORs of all the haplotypes of CYP3A4, UGT1A1, UGT1A3, MDR1 and OATP2 genes were not statistically significant (OR = 0.371-2.118, p = 0.06-0.93). Conclusion: Variant UGT1A1 gene is related to cholesterol-lowing effects in Taiwanese patients treated with atorvastatin. Determination of UGT1A1 gene can be considered for the selection of effective-outcome patients prior to giving of atorvastatin. The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 125995-03-1 is helpful to your research., Electric Literature of 125995-03-1
Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics