name: 2,2,6,6-Tetramethyl-2H-3,5,6-trihydropyran-4-one. Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 1197-66-6, Name is 2,2,6,6-Tetramethyl-2H-3,5,6-trihydropyran-4-one. In a document type is Article, introducing its new discovery.
We describe the discovery of MK-6169, a potent and pan-genotype hepatitis C virus NS5A inhibitor with optimized activity against common resistance-associated substitutions. SAR studies around the combination of changes to both the valine and aminal carbon region of elbasvir led to the discovery of a series of compounds with substantially improved potency against common resistance-associated substitutions in the major genotypes, as well as good pharmacokinetics in both rat and dog. Through further optimization of key leads from this effort, MK-6169 (21) was discovered as a preclinical candidate for further development.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.name: 2,2,6,6-Tetramethyl-2H-3,5,6-trihydropyran-4-one, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1197-66-6, in my other articles.
Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics