7525-64-6, 4-Methyltetrahydro-2H-pyran-4-ol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
7525-64-6, Step 1. Preparation of (4-methyltetrahydropyran-4-yl)-(4-nitrophenyl)-carbonate In a flame-dried round bottomed flask equipped with a magnetic stirrer, 4-methyltetrahydropyran-4-ol (1.5 g, 12.9 mmol), prepared as described in patent application WO2004/041161, was dissolved in CH2Cl2 (30 mL). The mixture was chilled to 0 C. then pyridine (2.04 mL, 25.82 mmol, 2 eq) and p-nitrophenylchloroformate (3.38 g, 16.78 mmol) solution in CH2Cl2 (10 mL) were slowly added. A white precipitate almost immediately appeared and the mixture was stirred overnight at rt. The crude mixture was then diluted with CH2Cl2, washed with 1M HCl solution, saturated NaHCO3 solution and finally with brine. The two phases were separated and the organic one was dried over Na2SO4. Removal of the organics under reduced pressure gave a crude yellow solid (3.8 g), as a 1:1 mixture of desired product and p-nitrophenylchloroformate, which was used in the next step without further purification. 1H NMR (CDCl3): delta 1.67 (s, 3H), 1.87 (m, 2H), 2.23 (m, 2H), 3.78 (m, 4H), 7.39 (d, J=9.0 Hz, 2H), 8.29 (d, J=9.0 Hz, 2H)
The synthetic route of 7525-64-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino ?Carlo Bo?; Piomelli, Daniele; Bandiera, Tiziano; Mor, Marco; Tarzia, Giorgio; Bertozzi, Fabio; Ponzano, Stefano; (102 pag.)US9353075; (2016); B2;,
Tetrahydropyran – Wikipedia
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