The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.51673-83-7, Name is Tetrahydro-2H-pyran-2-carboxylic acid, molecular formula is C6H10O3. In a Article£¬once mentioned of 51673-83-7, SDS of cas: 51673-83-7
Synthesis and antitumour activity of beta-hydroxyisovalerylshikonin analogues
A series of novel beta-hydroxyisovalerylshikonin analogues bearing oxygen-containing substituents at the side-chain hydroxyl of shikonin were designed and synthesized. The cytotoxicities of these compounds were evaluated in vitro against multi-drug resistant (MDR) cell lines DU-145 and HeLa. Most compounds exhibited significant inhibitory activity on both cell lines. The structure-activity relationship showed the analogues with ether substituents displayed the most potent antitumour activity and selective cytotoxicity towards DU-145. Among the compounds with ether substituents, increasing the steric hindrance in the carbon bearing beta-hydroxyl or replace the beta-hydroxyl with acetoxy or methoxy would lead to the decline of cytotoxicity.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.SDS of cas: 51673-83-7, you can also check out more blogs about51673-83-7
Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics