With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228779-96-1,3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide,as a common compound, the synthetic route is as follows.
To the reaction flask was added 35 g of Ven-18 (80 mmol) and 1000 mL of dichloromethane, 22.8 g of Ven-21(80 mmol), 17.7 g of DMAP (160 mmol) and 27.8 g (160 mmol) of EDCI at 30 C for about 24 hours.Should be completely followed by 900 mL of 10% aqueous acetic acid, 900 mL of saturated aqueous sodium bicarbonate, 900 mL of water, 900 mL of saturated foodWashed with brine, dried over anhydrous sodium sulfate and concentrated to dryness to give a crude product (56 g) as a yellow solid. The crude product was recrystallized from 1000 mL of acetonitrile,Filtration, filter cake 200mL acetonitrile washing, drying yellow powdery solid 47g, the yield of 80%. HPLC purity: 99%.
1228779-96-1, As the paragraph descriping shows that 1228779-96-1 is playing an increasingly important role.
Reference£º
Patent; Hangzhou Keyao Pharmaceutical Technology Co., Ltd.; Zhou Junming; (10 pag.)CN107089981; (2017); A;,
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