1194-16-7, 2,2-Dimethyltetrahydropyran-4-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example B15a and B15b: 7,7-dimethyloxepan-4-one and 2,2-dimethyloxepan-4-one Into a 100-mL 3 -necked round-bottom flask purged and maintained with nitrogen atmosphere was placed a solution of 2,2-dimethyloxan-4-one (1.3 g, 10.14 mmol, 1.00 equiv) in dichloromethane (40 mL) and boron fluoride ethyl ether (1.4 mL, 1.10 equiv). TMSCHN2 (6 mL, 1.10 equiv, 2mol/L in hexane) was added dropwise at -30C. The resulting solution was stirred for 1 h at -30 C and TLC (PE:EA=5:l)showed conversion was almost complete. The reaction was quenched with saturated sodium bicarbonate, extracted with 3×100 mL of dichloromethane. The organic layers were dried over anhydrous sodium sulfate and concentrated under vacuum. This resulted in 1.5g of crude yellow oil as a mixture of 2,2-dimethyloxepan-4-one and 7,7- dimethyloxepan-4-one ., 1194-16-7
The synthetic route of 1194-16-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; F.HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BROOKFIELD, Frederick; BURCH, Jason; GOLDSMITH, Richard A.; HU, Baihua; LAU, Kevin Hon Luen; MACKINNON, Colin H.; ORTWINE, Daniel Fred; PEI, Zhonghua; WU, Guosheng; YUEN, Po-wai; ZHANG, Yamin; WO2014/23258; (2014); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics