With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36838-71-8,4-Methylenetetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.
EXAMPLE H8: 4-r((2/?.5S)-44f3-r(5-fluoro-2-methylpyrimidin-4-yl)aminol-6.6- dimethyl^.beta-dihvdropyrrolora^-cipyrazol-SdHWIlcarbonvD^.delta- dimethylpiperazin-1-yl)methyl1tetrahvdro-2H-pyran-4-ol; Intermediate H8(i): 1 ,6-dioxaspiro[2.5]octane; A solution of 4-methylenetetrahydro-2/-/-pyran (1.00 g, 10.2 mmol) in CH2CI2 (30 ml_) was placed in an ice bath then mef¡ã-chloroperoxybenzoic acid (2.46 g, 14.3 mmol) was added in three portions. The reaction was slowly warmed to RT and stirred for 3h then quenched with 10% NaOH(aq) (10 ml_) and extracted withCH2CI2 (2 x 15 ml_). The combined extracts were dried (MgSO4), filtered and concentrated to provide intermediate H8(i) as a clear oil (607 mg, 52%)., 36838-71-8
36838-71-8 4-Methylenetetrahydro-2H-pyran 548975, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; PFIZER INC.; WO2008/96260; (2008); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics