125995-03-1, Atorvastatin lactone is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,125995-03-1
An authentic sample of Lactone (530mg) was dissolved in anhydrous DMF (5ML), followed by imidazole (174mg), then TBDMS chloride (371 mg). The mixture was stirred at room temperature. After 6 hours, the reaction was worked up by addition of ET20 (30ML) and water (30ML). The separated organic phase was further washed with water (2 x 20MOI), dried, and concentrated in vacuo to afford silylated lactone as a white powder (470mg, 73%). The silylated lactone (233mg) was dissolved in anhydrous dichloromethane (5ML), then COOLED TO-78C under Nitrogen. DIBAL (0. 31 ml, 1 M in toluene) was added dropwise and the mixture stirred for 10 minutes AT-78C. The mixture was then quenched by addition of 1 ml of 10% aqueous Rochelle’s salt and allowed to warm to room temperature. After addition of further DICHLOROMETHANE (10ML) and water (10MOI), the phases were separated and the organic phase dried and concentrated in vacuo. The residual oil was purified by column chromatography (50% ET20 in hexane). FTIR : 1668 CM~ (amide). Stretch at 1735CM (Lactone) no longer present. The silylated lactol (100mg) was dissolved in anhydrous THF. HF. pyridine was added (0. 1ML) at 0C and allowed to warm to room temperature. The mass was quenched with ether/and sodium bicarbonate solution. The phases separated and the aqueous phase back extracted with ether. The organic phases were combined, dried and evaporated to produce and oil (75mg). M/z 542,524, 506;’H nmr CDC13 1.3 (d, 6H), 1.6- 1.9 (m, 6H), 3.45 (2H), 3.6 (m, 2H), 3.8 (m, 1H), 5.0 (m, 1H), 6.8 (br. s 1H), 7.1 (m, 14H); 3C nmr CDCI3 91.6ppm (Lactol C); FTIR : 1652CM (Amide)
As the paragraph descriping shows that 125995-03-1 is playing an increasingly important role.
Reference£º
Patent; AVECIA LIMITED; WO2005/12246; (2005); A1;,
Tetrahydropyran – Wikipedia
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