101691-65-0, (Tetrahydro-2H-pyran-4-yl)methyl 4-methylbenzenesulfonate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
CsC03 (313 mg, 0.961 mmol) was added to a solution of ethyl 2-((3-(4-((2′- chloro-4′-hydroxy-[1 ,1 ‘-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)oxy)propanoate (357 mg, 0.739 mmol) in DMF (5 mL) and the reaction mixture was stirred at RT for 10 minutes followed by the addition of (tetrahydro-2H-pyran-4-yl)methyl 4- methylbenzenesulfonate (commercial sources, 200 mg, 0.739 mmol). The reaction mixture was heated at 80 C for 2 hours. After completion of reaction the reaction mixture was quenched with ice-cold water and concentrated. The residue was dissolved in ethylacetate and washed with water. The organic layer was dried over anhydrous sodium sulphate, concentrated and purified by flash chromatography to obtain the title compound as semi solid (266 mg). Yield: 61.93%; 1H NMR (CDCI3, 300 MHz): delta 7.48 (s, 1H), 7.45-7.41 (m, 3H), 7.32-7.24 (m, 3H), 7.02-6.99 (m, 3H), 6.88-6.84 (m, 1H), 5.13 (s, 2H), 5.04 (d, J = 6.6 Hz, 1H), 4.95-4.86 (m, 3H), 4.06- 4.05 (m, 2H), 4.01-3.94 (m, 2H), 3.85-3.77 (m, 3H), 3.50-3.42 (m, 2H), 2.07-2.09 (m, 1H), 1.79-1.75 (m, 2H), 1.50-1.46 (m, 2H),1.32 (d, J= 6.9 Hz, 3H), 1.16 (t, J= 7.2 Hz, 3H); MS (m/z) 603.2 [M+ Na]., 101691-65-0
The synthetic route of 101691-65-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PIRAMAL ENTERPRISES LIMITED; SHARMA, Rajiv; HALDER, Somnath; KUMAR, Sanjay; WO2014/170842; (2014); A2;,
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