2081-44-9, Tetrahydro-2H-pyran-4-ol is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 1: Methanesulfonic acid tetrahydro-pyran-4-yl esterTo a solution of tetrahydro-2H-pyran-4-ol (25 g, 245 mmol) and triethyl amine (40.1 ml, 294 mmol) in CH2C12 (500 ml) at 0C was added dropwise methanesulfonylchloride (20.7 ml, 269 mmol) over a period of 40 mm, keeping the temperature between 0 – 4C. The reaction mixture was then allowed to stir at 0C for lhr. The cooling bath was removed and the mixture was stirred for another 90 mins at 25C. The mixture was washed with water (2 x 125m1), dried over anhydrous Na2504, filtered and concentrated under vacuum to get methanesulfonic acid tetrahydro-pyran-4-yl ester (38 g, 86%; crude) as liquid that was used in the next step without any further purification.
2081-44-9, The synthetic route of 2081-44-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GROEBKE ZBINDEN, Katrin; PINARD, Emmanuel; RYCKMANS, Thomas; WO2015/110370; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics