With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125552-89-8,4-(Bromomethyl)tetrahydropyran,as a common compound, the synthetic route is as follows.
Ethyl 2,4-dioxo-3- (p-tolyl) -1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (3.76 g, 13.7 mmol, 1.0 eq) was dissolved in DMF (45 mL) To this, 4- (bromomethyl) tetrahydro-2H-pyran (4.88 g, 27.4 mmol, 2.0 eq) and potassium carbonate (5.67 g, 41.1 mmol, 3.0 eq) were added. The reaction was heated to 60 C for 4 hours. After the reaction was detected by LC-MS and TLC, the temperature was lowered to room temperature, suction filtered, the filtrate was poured into water (50mL), and extracted with EA (50mL ¡Á 3). The organic phases were combined, washed with brine three times, dried, filtered, and concentrated. Silica gel column chromatography (100-200 mesh silica gel, PE / EA = 0-50%) was purified to obtain an off-white solid (1.9 g, yield: 37%)., 125552-89-8
125552-89-8 4-(Bromomethyl)tetrahydropyran 2773286, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Li Lin; Wan Zhonghui; (107 pag.)CN110041316; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics