1240390-36-6, tert-Butyl ((3R,4R)-4-aminotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(3R,4R)-4-(6-Carbamoyl-5-(6-isopropoxypyridin-2-ylamino)pyridazin-3-ylamino)tetrahydro-2H-pyran-3-ylcarbamate [0524] [0525] To a solution of 6-chloro-4-(6-isopropoxypyridin-2-ylamino)pyridazine-3-carboxamide (270 mg, 877 mumol, Eq: 1.00) in NMP (3.51 mL) was added tert-butyl (3R,4R)-4-aminotetrahydro-2H-pyran-3-ylcarbamate (190 mg, 877 mumol, Eq: 1.00) and the mixture heated to 140 C. Over the next 36 hrs three additional portions of amine were added at 12 h intervals. At 48 hrs the mixture was cooled, diluted with EtOAc, and washed with water and brine (2¡Á). The organic layer was concentrated onto silica and purified by chromatography (70% to 100% EtOAc/hexanes) to (3R,4R)-4-(6-carbamoyl-5-(6-isopropoxypyridin-2-ylamino)pyridazin-3-ylamino)tetrahydro-2H-pyran-3-ylcarbamate (190 mg, 44.4%). 1H NMR (400 MHz, CHLOROFORM-d6) delta ppm 11.37 (s, 1H), 8.06 (s, 1H), 7.92 (s, 1H), 7.49 (t, J=7.5 Hz, 1H), 6.44 (d, J=8.0 Hz, 1H), 6.31 (d, J=8.2 Hz, 1H), 5.91 (s, 1H), 5.67 (s, 1H), 5.38 (d, J=8.5 Hz, 1H), 5.15 (m, 1H), 4.30 (m, 1H), 4.05 (s, 1H), 4.00 (d, J=12.5 Hz, 1H), 3.90 (d, J=12.3 Hz, 1H), 3.68 (d, J=11.3 Hz, 1H), 3.61 (t, J=10.8 Hz, 1H), 2.27 (s, 1H), 1.79 (m, 1H), 1.44 (m, 15H).
1240390-36-6 tert-Butyl ((3R,4R)-4-aminotetrahydro-2H-pyran-3-yl)carbamate 68077633, aTetrahydropyrans compound, is more and more widely used in various.
Reference£º
Patent; Hoffman-La Roche Inc.; Hermann, Johannes Cornelius; Kennedy-Smith, Joshua; Lucas, Matthew C.; Padilla, Fernando; Soth, Michael; US2013/178478; (2013); A1;,
Tetrahydropyran – Wikipedia
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