With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1408168-76-2,Potassium trifluoro(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)borate,as a common compound, the synthetic route is as follows.
To a degassed solution of intermediate (10e) (1.35 g, 2.60 mmol) in toluene (15 ml_) and water (5 ml_) were added potassium 2-(tetrahydro-2/-/-pyran-2-yloxy)ethyltrifluoroborate (613 mg, 2.60 mmol), cesium carbonate (2.54 g, 7.79 mmol), RuPhos (121 mg, 0.26 mmol) and palladium(ll) acetate (29 mg, 0.13 mmol). The flask was sealed and the mixture was heated at 95C for 5h. The mixture was cooled to rt and water was added. The layers were separated. The aqueous layer was extracted with toluene. The combined organic layers were washed with brine, dried over Na2S04 and concentrated in vacuo. The residue was purified by flash chromatography on silica gel (cyclohexane/ AcOEt 10/0 to 5/5) to provide intermediate (1 1 a) (1 .21 g, 2.12 mmol, 81%) as a yellow oil. MS m/z ([M+Na]+) 591., 1408168-76-2
The synthetic route of 1408168-76-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MUTABILIS; BARBION, Julien; CARAVANO, Audrey; CHASSET, Sophie; CHEVREUIL, Francis; LE STRAT, Frederic; SIMON, Christophe; BRIAS, Julie; LEBEL, Remi; (80 pag.)WO2020/25543; (2020); A1;,
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