With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.185815-59-2,4-Isobutyldihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.
In a 100mL three-necked flask, under nitrogen, was added thereto 3-isobutylglutaric anhydride (1.70g, 0.01mol), (S)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N,N,4-trimethyl-N-(4-nitrobenzyl) pentan-1-ylammonium chloride (590mg, 1.0mmol), and 50mL methyl tert-butyl ether to dissolve solids. At -10C, was added with stirring benzyl mercaptan (1.50g, 0.012mol). It was stirred for 16h. The solvent was removed under reduced pressure to give the thiol ester 2.84g, yield 96%, ee value of 95%.
185815-59-2, 185815-59-2 4-Isobutyldihydro-2H-pyran-2,6(3H)-dione 11480690, aTetrahydropyrans compound, is more and more widely used in various fields.
Reference£º
Patent; Shenzhen Huaxian Pharmaceutical Tech Co., Ltd.; Lan, Wenlong; (9 pag.)CN105753726; (2016); A;,
Tetrahydropyran – Wikipedia
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