25637-16-5, 4-Bromotetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 6 (300 mg, 1.60 mmol) in DMF (3 mL) was added sodium hydride (95 mg, 60% dispersion in mineral oil, 2.38 mmol) and 4-bromo-tetrahydro-2H-pyran (458 mg, 1.75 mmol). The resulting mixture was stirred for 18 h at room temperature. The reaction mixture was diluted with water (25 mL) and extracted with EtOAc (2 x 50 mL). The combined organic extracts were dried over MgSO4, filtered, and concentrated. The resultant residue was purified by column chromatography (0-5% gradient of EtOAc in hexane) to provide the title compound (340 mg, 78%) as a colouless oil. 1H NMR (400 MHz, CDCl3) ppm 1.60 – 1.76 (m, 2 H), 1.92 (dd, J = 11.87, 1.52 Hz, 2 H), 3.20 – 3.33 (m, 1 H), 3.39 – 3.51 (m, 2 H), 3.93 – 4.05 (m, 2 H), 7.28 – 7.34 (m, 2 H), 7.42 – 7.49 (m, 2 H)., 25637-16-5
The synthetic route of 25637-16-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Semple, Graeme; Santora, Vincent J.; Smith, Jeffrey M.; Covel, Jonathan A.; Hayashi, Rena; Gallardo, Charlemagne; Ibarra, Jason B.; Schultz, Jeffrey A.; Park, Douglas M.; Estrada, Scott A.; Hofilena, Brian J.; Smith, Brian M.; Ren, Albert; Suarez, Marissa; Frazer, John; Edwards, Jeffrey E.; Hart, Ryan; Hauser, Erin K.; Lorea, Jodie; Grottick, Andrew J.; Bioorganic and Medicinal Chemistry Letters; vol. 22; 1; (2012); p. 71 – 75;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics