125552-89-8, 4-(Bromomethyl)tetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of N-(2-hydroxyethyl)-4-(2H-tetrazol-5-yl)benzenesulfonamide (200 mg, 0.743 mmol, Intermediate 17) in Lambda/,/V-dimethylformamide (10 ml_), potassium carbonate (205 mg, 1 .485 mmol, commercial source: RCP) was added followed by the addition of 4- (bromomethyl)tetrahydro-2H-pyran (159 mg, 0.88 mmol, commercial source: Aldrich) at 26 C. The reaction mixture was heated to 80 C for 8 h. Upon completion, the reaction mixture was cooled to 26 C and evaporated under reduced pressure. The crude was purified by column chromatography (silicagel 100-200 mesh), eluted with 5% methanol in dichloromethane. The pure fractions were concentrated under reduced pressure to afford N- (2-hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)methyl)-2H-tetrazol-5- yl)benzenesulfonamide (80 mg, 18%).1H NMR (400 MHz, DMSO-de) delta 8.28-8.24 (m, 2H), 7.98 (d, J = 8.6 Hz, 2H), 7.79-7.72 (m, 1 H), 4.73-4.65 (m, 3H), 3.88-3.80 (m, 2H), 3.38 (q, J = 6.1 Hz, 2H), 3.29-3.27 (m, 2H), 2.85 (q, J = 5.3 Hz, 2H), 2.35-2.23 (m, 1 H), 1.52-1.46 (m, 2H), 1.40-1.31 (m, 2H). MS m/z [M+H]+= 368.12.
125552-89-8, As the paragraph descriping shows that 125552-89-8 is playing an increasingly important role.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ALEMPARTE-GALLARDO, Carlos; ENCINAS, Lourdes; ESQUIVIAS PROVENCIO, Jorge; (206 pag.)WO2019/34729; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics