Category: 108-55-4

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 108-55-4, Name is Dihydro-2H-pyran-2,6(3H)-dione, molecular formula is C5H6O3. In an article, author is Rusere, Linah N.,once mentioned of 108-55-4, Category: Tetrahydropyrans.

Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere

The design, synthesis, and X-ray structural analysis of hybrid HIV-1 protease inhibitors (PIs) containing bis-tetrahydrofuran (bis-THF) in a pseudo-C-2-symmetric dipeptide isostere are described. A series of PIs were synthesized by incorporating bis-THF of darunavir on either side of the Phe-Phe isostere of lopinavir in combination with hydrophobic amino acids on the opposite P2/P2′ position. Structure-activity relationship studies indicated that the bis-THF moiety can be attached at either the P2 or P2′ position without significantly affecting potency. However, the group on the opposite P2/P2′ position had a dramatic effect on potency depending on the size and shape of the side chain. Cocrystal structures of inhibitors with wild-type HIV-1 protease revealed that the bis-THF moiety retained similar interactions as observed in the darunavir-protease complex regardless of the position on the Phe-Phe isostere. Analyses of cocrystal structures and molecular dynamics simulations provide insights into optimizing HIV-1 PIs containing bis-THF in non-sulfonamide dipeptide isosteres.

Interested yet? Keep reading other articles of 108-55-4, you can contact me at any time and look forward to more communication. Category: Tetrahydropyrans.

Reference:
Tetrahydropyran – Wikipedia,
,Tetrahydropyran – an overview | ScienceDirect Topics

In an article, author is Chen, Jing, once mentioned the application of 108-55-4, SDS of cas: 108-55-4, Name is Dihydro-2H-pyran-2,6(3H)-dione, molecular formula is C5H6O3, molecular weight is 114.0993, MDL number is MFCD00006679, category is Tetrahydropyrans. Now introduce a scientific discovery about this category.

Removal of gaseous tetrahydrofuran via a three-phase airlift bioreactor loaded with immobilized cells of GFP-tagged Pseudomonas oleovorans GDT4

Tetrahydrofuran (THF) is a common highly toxic cyclic aliphatic ether that frequently exists in waste gases. Removal of gaseous THF is a serious issue with important environmental ramifications. A novel three-phase airlift bioreactor (TPAB) loaded with immobilized cells was developed for efficient THF removal from gas streams. An effective THF-degrading transformant, Pseudomonas oleovorans GDT4, which contains the pTn-Mod-OTc-gfp plasmid and was tagged with a green fluorescent protein (GFP), was constructed. Continuous treatment of THF-containing waste gases was succeeded by the GFP-labelled cells immobilized with calcium alginate and activated carbon fiber in the TPAB for 60 days with >90% removal efficiency. The number of fluorescent cells in the beads reached 1.7 x 10(11) cells.g(-1) of bead on day 10, accounting for 83.3% of the total number of cells. The amount further increased to 3.0 x 10(11) cells.g(-1) of bead on day 40. However, it decreased to 2.5 x 10(11) cells.g(-1) of bead with a substantial increase in biomass in the liquid because of cell leakage and hydraulic shock. PCR-DGGE revealed that P. oleovorans was the dominant microorganism throughout the entire operation. The maximum elimination capacity was affected by empty bed residence time (EBRT). The capacity was only 25.9 g M-3.h(-1) at EBRT of 80 s, whereas it reached 37.8 g m(-3).h(-1) at EBRT of 140 s. This work provides an alternative method for full-scale removal of gaseous THF and presents a useful tool for determining the biomass of a specific degrader in immobilized beads. (C) 2020 Elsevier Ltd. All rights reserved.

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Reference:
Tetrahydropyran – Wikipedia,
,Tetrahydropyran – an overview | ScienceDirect Topics

Reference of 108-55-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 108-55-4, Name is Dihydro-2H-pyran-2,6(3H)-dione, SMILES is O=C1CCCC(O1)=O, belongs to Tetrahydropyrans compound. In a article, author is Li Rongye, introduce new discover of the category.

pH/Solvent Tunable Hierarchical Nanostructures Assembled from an Amphiphilic Polypeptide-containing Triblock Copolymer

Similar to natural proteins, polypeptides can form secondary structures depending on their physical properties. Many efforts have been made towards the self-assembly of triblock copolymer containing polypeptide as an important component to construct hierarchical structures by utilizing the pH-responsive conformation transformation. In this work, a pH-responsive poly(ethylene glycol)-b-poly(L-lysine)-b-poly(styrene) (PEG-b-PLL-b-PS) triblock copolymer was prepared via a combination of controlled ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP). In the triblock copolymer, PLL is water-soluble in acidic solution with random coil conformation, but becomes insoluble helix in alkaline solution. PEG has excellent water solubility that can exhibit protein-resistant property. PS serves as hydrophobic part. Self-assembly of the polymer was examined by transmission electron microscopy (TEM), atomic force microscopy (AFM) and attenuated total reflection-infrared spectrometer (ATR-IR). The triblock copolymer forms spherical micelles in 1 : 1 volume ratio of tetrahydrofuran-water mixed solvent, in which the hydrophobic PS segment forms a core and the two hydrophilic segments PLL and PEG serve as shell and corona, respectively. The spheres as the subunits further transform into hierarchical 1D fiber-like structure in the presence of THE’ after 7 d of aging, confirmed by both TEM and AFM techniques. Upon removing THF, the spherical shape was re-obtained with slightly smaller diameter, so called frozen micelles. Further, the diameter of the spheres increases with pH increasing. A sphere-to-vesicle transition was observed at pH 13 as the secondary conformation of PLL transforms from coil to a-helix. The dialysis of these solutions can convert the vesicles back into spherical morphology with slightly smaller diameter.

Reference of 108-55-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 108-55-4.

Reference:
Tetrahydropyran – Wikipedia,
,Tetrahydropyran – an overview | ScienceDirect Topics

Electric Literature of 108-55-4, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 108-55-4, Name is Dihydro-2H-pyran-2,6(3H)-dione, SMILES is O=C1CCCC(O1)=O, belongs to Tetrahydropyrans compound. In a article, author is Bhattacharjee, Gaurav, introduce new discover of the category.

Ultra-rapid uptake and the highly stable storage of methane as combustible ice

The continuously increasing trend of natural gas (NG) consumption due to its clean nature and abundant availability indicates an inevitable transition to an NG-dominated economy. Solidified natural gas (SNG) storage via combustible ice or clathrate hydrates presents an economically sound prospect, promising high volume density and long-term storage. Herein, we establish 1,3-dioxolane (DIOX) as a highly efficient dual-action (thermodynamic and kinetic promoter) additive for the formation of clathrate (methane sII) hydrate. By synergistically combining a small concentration (300 ppm) of the kinetic promoter L-tryptophan with DIOX, we further demonstrated the ultra-rapid formation of hydrates with a methane uptake of 83.81 (+/- 0.77) volume of gas/volume of hydrate (v/v) within 15 min. To the best of our knowledge, this is the fastest reaction time reported to date for sII hydrates related to SNG technology and represents a 147% increase in the hydrate formation rate compared to the standard water-DIOX system. Mixed methane-DIOX hydrates in pelletized form also exhibited incredible stability when stored at atmospheric pressure and moderate temperature of 268.15 K, thereby showcasing the potential to be industrially applicable for the development of a large-scale NG storage system.

Electric Literature of 108-55-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 108-55-4 is helpful to your research.

Reference:
Tetrahydropyran – Wikipedia,
,Tetrahydropyran – an overview | ScienceDirect Topics

Chemistry is an experimental science, SDS of cas: 108-55-4, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 108-55-4, Name is Dihydro-2H-pyran-2,6(3H)-dione, molecular formula is C5H6O3, belongs to Tetrahydropyrans compound. In a document, author is Kailash, S..

Conjugated hydrophobic and hydrophilic blocks through a drug moiety as a leading macromolecular system for sustainable drug delivery

Ring-opening polymerization (ROP) of epsilon-caprolactone (CL) had been performed at 160 degrees C in the presence of drug molecules such as penicillin g (Pen), streptavidin (Strep) and terramicin (Ter) as a lone chemical initiator using the catalyst, stannous octoate (SO) under N-2 atmosphere. The prepared drug bridged poly (epsilon-caprolactone) (PCL) was further copolymerized with tetrahydrofuran (THF) and the diblock copolymers were examined using the various analytical tools (FT-IR, DSC, TGA, SEM, FE-SEM, EDX, UV-visible and GPC). The functionalities of the drug bridged diblock copolymers were concluded by FT-IR spectra. The formation of the diblock copolymer was further understood from the increase in M-w. The drug release activity of homo and diblock copolymer had been tested with the drug release model and mechanism. The mechanical properties are also studied.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 108-55-4, in my other articles. SDS of cas: 108-55-4.

Reference:
Tetrahydropyran – Wikipedia,
,Tetrahydropyran – an overview | ScienceDirect Topics

In an article, author is Das, Ashrukana, once mentioned the application of 108-55-4, Name is Dihydro-2H-pyran-2,6(3H)-dione, molecular formula is C5H6O3, molecular weight is 114.0993, MDL number is MFCD00006679, category is Tetrahydropyrans. Now introduce a scientific discovery about this category, Formula: C5H6O3.

Design of configuration-restricted triazolylated beta-d-ribofuranosides: a unique family of crescent-shaped RNase A inhibitors

Seven new carbohydrate-bistriazole hybrid molecules were designed taking into consideration the crescent shaped active site of ribonuclease A (RNase A). In this case, the beta-d-ribofuranose structure was used as the basic building unit; both the C1 and C4 arms protruding out towards the beta-face of the tetrahydrofuran moiety of the ribose sugar provided an overall U shape to the basic building block. Several combinations of bistriazole moieties were constructed on the two arms of this basic building block. These mono- and/or bis-substituted 1,2,3-triazole units were linked to acidic functional groups because of the overall basic nature of the hydrolytic site of RNase A. All these compounds were efficient competitive inhibitors of RNase A with inhibition constants (K-i) in the micromolar range. In contrast to the carboxylic acid-modified hybrid molecules, molecules carrying sulfonic acids were found to be more potent because of the stronger interactions with the positively charged active site. The most efficient inhibitor of the series was the disulfonic acid-functionalized carbohydrate-bis-triazole hybrid molecule. Docking studies disclosed that the molecule, because of its well defined U shape with flexible arms, fits effectively in the active site; moreover, in all cases, besides the acid groups, the triazole and sugar rings also actively participated in creating the hydrogen bonding network in the cavity of the enzyme active site.

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Reference:
Tetrahydropyran – Wikipedia,
,Tetrahydropyran – an overview | ScienceDirect Topics

Chemistry is an experimental science, HPLC of Formula: C5H6O3, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 108-55-4, Name is Dihydro-2H-pyran-2,6(3H)-dione, molecular formula is C5H6O3, belongs to Tetrahydropyrans compound. In a document, author is Collins, Tyler S..

Origin of Bond Elongation in a Uranium(IV) cis-Bis(imido) Complex

The activation of U-N multiple bonds in an imido analogue of the uranyl ion is accomplished by using a system that is very electron-rich with sterically encumbering ligands. Treating the uranium(VI) trans-bis(imido) UI2(NDIPP)(2)(THF)(3) (DIPP = 2,6-diisopropylphenyl and THF = tetrahydrofuran) with tert-butyl(dimethylsilyl)amide (NTSA) results in a reduction and rearrangement to form the uranium(IV) cis-bis(imido) [U(NDIPP)(2)(NTSA)(2)]K-2 (1). Compound 1 features long U-N bonds, pointing toward substantial activation of the N=U=N unit, as determined by X-ray crystallography and H-1 NMR, IR, and electronic absorption spectroscopies. Computational analyses show that uranium(IV)-imido bonds in 1 are significantly weakened multiple bonds due to polarization toward antibonding and nonbonding orbitals. Such geometric control has important effects on the electronic structures of these species, which could be useful in the recycling of spent nuclear fuels.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 108-55-4, in my other articles. HPLC of Formula: C5H6O3.

Reference:
Tetrahydropyran – Wikipedia,
,Tetrahydropyran – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 108-55-4, Name is Dihydro-2H-pyran-2,6(3H)-dione, molecular formula is C5H6O3, belongs to Tetrahydropyrans compound. In a document, author is Zhang, Changhuan, introduce the new discover, Category: Tetrahydropyrans.

Studies of FeSe(2)Cathode Materials for Mg-Li Hybrid Batteries

Rechargeable magnesium (Mg)-based energy storage has attracted extensive attention in electrochemical storage systems with high theoretical energy densities. The Mg metal is earth-abundant and dendrite-free for the anode. However, there is a strong Coulombic interaction between Mg(2+)and host materials that often inhibits solid-state diffusion, resulting in a large polarization and poor electrochemical performances. Herein, we develop a Mg-Li hybrid battery using a Mg-metal anode, an FeSe(2)powder with uniform size and a morphology utilizing a simple solution-phase method as the counter electrode and all-phenyl-complex/tetrahydrofuran (APC)-LiCl dual-ion electrolyte. In the Li+-containing electrolyte, at a current density of 15 mA g(-1), the Mg-Li hybrid battery (MLIB) delivered a satisfying initial discharge capacity of 525 mAh g(-1). Moreover, the capacity was absent in the FeSe2|APC|Mg cell. The working mechanism proposed is the Li+-only intercalation at the FeSe(2)and the Mg(2+)dissolved or deposited at the Mg foil in the FeSe2|Mg2+/Li+|Mg cell. Furthermore, ex situ XRD was used to investigate the structural evolution in different charging and discharging states.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 108-55-4. Category: Tetrahydropyrans.

Reference:
Tetrahydropyran – Wikipedia,
,Tetrahydropyran – an overview | ScienceDirect Topics

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , COA of Formula: C5H6O3, 108-55-4, Name is Dihydro-2H-pyran-2,6(3H)-dione, molecular formula is C5H6O3, belongs to Tetrahydropyrans compound. In a document, author is Panatdasirisuk, Weerapha, introduce the new discover.

Bromelain Immobilized onto Diamine-functionalized Electrospun Polyvinyl Chloride Fibers as a Durable Heterogeneous Catalyst

The best condition to produce smooth polyvinyl chloride (PVC, M.W. similar to 6.4×10(4) g/mol) fibers (572 +/- 171 nm) was 10 % w/v PVC in a mixture of tetrahydrofuran and dimethyl sulfoxide (4:1 by volume) with 5 % w/w Tween 20, 15 kV, 10 cm, and 3 ml/h. PVC fibers were subjected to plasma surface treatment to make them more hydrophilic. Diameters of the treated fibers were 549 +/- 99 nm. Next, the PVC fibers were treated with ethylene diamine (EDA) and p-phenylenediamine (PDA) to obtain PVC-EDA and PVC-PDA, respectively. Bromelain was immobilized onto PVC-EDA and PVC-PDA by an aid of 1 % w/v glutaraldehyde to receive PVC-EDA-bromelain and PVC-PDA-bromelain with good tensile strengths of similar to 19 and similar to 14 MPa, respectively. The activities of free and immobilized bromelain were assayed by casein as a substrate and a spectrophotometer at 275 nm. Bromelain loadings on PVC-EDA-bromelain and PVC-PDA-bromelain were 88.10 +/- 3.54 and 36.38 +/- 18.10 mg/g of fibers, respectively. The kinetic activities of bromelain, PVC-EDA-bromelain, and PVC-PDA-bromelain were 11.31 +/- 2.17, 0.31 +/- 0.03, and 2.15 +/- 1.34 min(-1), respectively. PVC-EDA-bromelain and PVC-PDA-bromelain could be reused at least 9 times with > 50 % relative activities and endured heat (50-90 degrees C) better than free bromelain did. Their relative activities were > 70 % after storage at 90 degrees C for 20 min.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 108-55-4. COA of Formula: C5H6O3.

Reference:
Tetrahydropyran – Wikipedia,
,Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108-55-4,Dihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.

To a suspension of aluminum chloride (205.85 g, 1.54 mol) in dichloromethane (500 mL) was added a solution of glutaric anhydride (80 g, 0.7 mol) in dichloromethane (125 mL) at 0 C. The reaction mixture was stirred for 30 minutes. Fluorobenzene (67.36 g, 0.7 mol) was then added slowly. The progress of the reaction was monitored by TLC. Upon completion, the reaction mixture was poured into ice water (2000 mL) to precipitate a crude solid product, which was collected by filtration. The crude was re-dissolved in a 3% aqueous sodium hydroxide solution (1100 mL). After being washed with dichloromethane (300 mL), the aqueous solution was acidified to obtain a solid product. The product was filtered, washed with water, and vacuum dried to yield compound 3 (125 g). H NMR of compound 3 (CDCl3, 300M Hz): delta=2.10 (q, J=7.2 Hz, 2H), 2.51 (t, J=7.2 Hz, 2H), 3.65 (t, J=7.2 Hz, 2H), 7.13 (t, J=7.4 Hz, 2H), 7.98 (q, J=5.4 Hz, 2H)

108-55-4, 108-55-4 Dihydro-2H-pyran-2,6(3H)-dione 7940, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Heading (Nanjing) Pharmaceutical Technologies Co., Ltd.; Li, Wensen; Liu, Laiyue; Tang, Aichen; Wang, Yanmin; Wang, Hailong; Yu, Wansong; US2015/18565; (2015); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics