With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108-55-4,Dihydro-2H-pyran-2,6(3H)-dione,as a common compound, the synthetic route is as follows.
To a solution of 4 g (10.86 mmol) of curcumin, and 330 mg (2.71 mmol) of 4-dimethylaminopyridine (DMAP) in 140 ml tetrahydrofuran (THF), 2.27 ml (16.29 mmol) of Et3N was added. 1.42 g (12.49 mmol) of glutaric anhydride (95%) in 10 mL THF was slowly added dropwise to the curcumin solution. The mixture was stirred and refluxed under N2 atmosphere for 48 hrs. THF was removed under vacuum, redissolved in 100 mL CHCl3 and washed with 100 mL 0.1 N HCl followed by water (3¡Á50 mL) and brine (3¡Á50 mL). The organic layer was separated and dried over anhydrous Na2SO4. The product was purified via column chromatography, eluting with CHCl3:EtOAc (95:5) and isolated as orange powder. Yield: 64%. 1H NMR (CDCl3), delta (ppm): 2.10-2.12 (t, 2H); 2.56-2.58 (t, 2H); 2.69-2.72 (t, 2H); 3.87 (s, 3H); 3.94 (s, 3H); 5.83 (s, 2H); 6.48-6.57 (t, 2H); 6.48-6.57 (m, 1H); 6.94-7.16 (m, 5H); 7.59-7.62 (d, 2H). MS (ESI) calcd. for C26H26O9: 482.48. found: 483.2 [M+H]+.
108-55-4, The synthetic route of 108-55-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK; Banerjee, Probal; Krishnaswami, Raja; (15 pag.)US9446145; (2016); B2;,
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