With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125995-03-1,Atorvastatin lactone,as a common compound, the synthetic route is as follows.
Atorvastatin lactone (2.0 g) was dissolved in toluene (12.0 ml). To the clear solution so obtained, dimethyl sulfoxide (0.34 ml) was added under stirring. After the addition was complete the precipitated material was further stirred. The product was filtered under suction and dried under vacuum in oven. Crystalline atorvastatin lactone (1.8 g) as Form I was obtained. M.pt. 127-13O0C.
The synthetic route of 125995-03-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JUBILANT ORGANOSYS LIMITED; WO2006/67795; (2006); A2;,
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