Category: 1768-64-5

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Spleen tyrosine kinase (Syk) is an attractive drug target in autoimmune, inflammatory, and oncology disease indications. The most advanced Syk inhibitor, R406, 1 (or its prodrug form fostamatinib, 2), has shown efficacy in multiple therapeutic indications, but its clinical progress has been hampered by dose-limiting adverse effects that have been attributed, at least in part, to the off-target activities of 1. It is expected that a more selective Syk inhibitor would provide a greater therapeutic window. Herein we report the discovery and optimization of a novel series of imidazo[1,2-a]pyrazine Syk inhibitors. This work culminated in the identification of GS-9973, 68, a highly selective and orally efficacious Syk inhibitor which is currently undergoing clinical evaluation for autoimmune and oncology indications.

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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. In an article, once mentioned the application of 1768-64-5, Name is 4-Chlorotetrahydropyran,molecular formula is C5H9ClO, is a conventional compound. this article was the specific content is as follows.Formula: C5H9ClO

In the context of [3+6+3+6] macrocyclization reactions, precise kinetics of alpha-diazo-beta-ketoester decomposition were measured by in situ infrared (IR) monitoring. Dirhodium complexes of Ikegami-Hashimoto type – and perchlorinated phthalimido derivatives in particular – performed better than classical achiral complexes. Clear correlations were found between speciation among dirhodium species and catalytic activity. With these results, novel cyclohexyl-derived catalysts were developed, affording good yields of macrocycles (up to 78%), at low catalyst loadings (from 0.01 mol% to 0.001 mola?%) and on a large scale (from 1 g to 20 g).

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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Safety of 4-Chlorotetrahydropyran. Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 1768-64-5, Name is 4-Chlorotetrahydropyran. In a document type is Patent, introducing its new discovery.

The present invention relates to compounds of formula (I), wherein R1, R2, R1a, R1b have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. Introducing a new discovery about 1768-64-5, Name is 4-Chlorotetrahydropyran, SDS of cas: 1768-64-5.

The invention belongs to the chemical pharmaceutical intermediates synthesis technology field, in particular to a pharmaceutical bei Fu citalopram intermediate 4 – (2 – aminoethyl) tetrahydropyranylation synthetic method. The method comprises the following steps: (1) 4 – chlorine four hydrogen pyranes with cyanoacetic acid methyl ester reaction to obtain the 2 – cyano – 2 – (tetrahydro – 4 – pyranyl) acetic acid methyl ester; (2) 2 – cyano – 2 – (tetrahydro – 4 – pyranyl) methyl acetate obtained with protective cover (tetrahydro – 4 – pyranyl) – b nitriles; (3) (tetrahydro – 4 – pyranyl) – b nitrile C hydrogenation reaction to obtain 4 – (2 – aminoethyl) tetrahydropyran. The method adopts the 4 – chlorine four hydrogen pyranes, cyanoacetic acid methyl ester as the raw material, the method has short reaction time, low cost, easily available raw materials, non-toxic control and not stable chemical raw materials, safe and effective, the yield is high, less impurities. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.SDS of cas: 1768-64-5. This is the end of this tutorial post, and I hope it has helped your research about 1768-64-5

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Product Details of 1768-64-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount. 1768-64-5, Name is 4-Chlorotetrahydropyran, molecular formula is C5H9ClO. In a patent, introducing its new discovery.

A halotetrahydropyran is oxidized and dehydrohalogenated employing oxygen and a free radical initiator. 4-Chlorotetrahydropyran is converted to 5,6-dihydro-1,2-pyrone using 2,2′-azobis(2-methylpropionitrile) under elevated oxygen pressure and at a temperature of the order of about 170F.

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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. Introducing a new discovery about 1768-64-5, Name is 4-Chlorotetrahydropyran, COA of Formula: C5H9ClO.

Two different methods are tested for the determination of conformational free energy differences DeltaG in some halo heteracyclohexanes by infrared spectroscopy.Both methods allow a semiquantitative determination of the DeltaG-values in these compounds.The results are critically discussed and compared with n.m.r.-measurements.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 1768-64-5 is helpful to your research., COA of Formula: C5H9ClO

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction 1768-64-5, Name is 4-Chlorotetrahydropyran, molecular formula is C5H9ClO. In a Patent，once mentioned of 1768-64-5, SDS of cas: 1768-64-5

Certain 1H-imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydro-1H-imidazo[4,5-c]quinolines, 1H-imidazo[4,5-c][1,5]naphthyridines, 6,7,8,9-tetrahydro-1H-imidazo[4,5-c][1,5]naphthyridines, and 1H-imidazo[4,5-c]pyridines substituted at the 1- and 2-positions, pharmaceutical compositions containing these compounds, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.SDS of cas: 1768-64-5. In my other articles, you can also check out more blogs about 1768-64-5

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition. 1768-64-5, Name is 4-Chlorotetrahydropyran, molecular formula is C5H9ClO. In a Patent，once mentioned of 1768-64-5, Product Details of 1768-64-5

The compound of formula (I), pharmaceutically acceptable salts thereof, solvates thereof, chelates thereof, non-covalent complex thereof or produgs of compounds mentioned above or the mixture of any form above mentioned are provided. The use of the compounds in manufacturing a medicament for the treatment and/or prevention of diabetes, obesity and related disorders

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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

You could be based in a university, combining chemical research with teaching; in a pharmaceutical company, working on developing and trialing new drugs; helping to ensure national healthcare provision keeps pace with new discoveries. 1768-64-5, Name is 4-Chlorotetrahydropyran, molecular formula is C5H9ClO. In a Article，once mentioned of 1768-64-5, Formula: C5H9ClO

An effective and sensitive method for the analysis of 1,4-dioxane in water has been available since 2008 (EPA 522). This method is increasingly being applied to investigate the distribution of 1,4-dioxane in the aquatic environment. However, there is a need for more information about the possible occurrence of 1,4-dioxane in groundwater in Europe in general, and in Germany in particular, where virtually no data have been collected so far. The possible contamination of groundwater with 1,4-dioxane is of relevance to Germany because up to 70% of Germany’s drinking water is obtained from groundwater and about 17% from river bank filtrate, which contains variable proportions of groundwater. The aim of the present study is to investigate selected and representative groundwater sites in Germany that have suspected occurrences of 1,4-dioxane. Five of the sites are well known for their volatile chlorinated hydrocarbon contamination, two sites have representative landfill leachate characteristics, and one site is negatively impacted by a detergent manufacturing plant. The presence of 1,4-dioxane was observed at each of these sites. Measured maximum concentration values ranged from 0.15 mug/L to 152 mug/L. An aquifer containing a trichloroethylene (TCE) plume with 1,4-dioxane as a co-contaminant was investigated in more detail. A perfect match was found between the concentrations of 1,4-dioxane and TCE in the vertical and horizontal distribution profiles. The results indicate the necessity for investigating groundwater contamination by 1,4-dioxane at sites with known 1,1,1-trichloroethane (TCA) and TCE contaminations, in landfill leachates, and at sites of detergent production.

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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1768-64-5, Name is 4-Chlorotetrahydropyran, Product Details of 1768-64-5.

A halotetrahydropyran is oxidized and dehydrohalogenated employing oxygen and a free radical initiator. 4-Chlorotetrahydropyran is converted to 5,6-dihydro-1,2-pyrone using 2,2′-azobis(2-methylpropionitrile) under elevated oxygen pressure and at a temperature of the order of about 170F.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Product Details of 1768-64-5. In my other articles, you can also check out more blogs about 1768-64-5

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics