1768-64-5, 4-Chlorotetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A stirred mixture of (S)-(+)-prolinol (0.4 14 g, 3.99 mmol), NiC12-glyme (0.449 g, 1.99 mmol), phenyl boronic acid (3.04 g, 24.98 mmol) and KHMDS (6.6 g, 33.3 mmol) was submitted to few cycles of vacuumlargon flow. i-PrOH (40 mL) was added and the resulting mixture was stirred at r.t. for 10 mm, then 4-chlorotetrahydropyran (1.75 mL, 16.6 mmol) wasadded dropwise. The resulting yellowish mixture was heated at 65 C for 50 h, then cooled at r.t., diluted with EtOAc (200 mL) and washed with 10% HC1 solution (30 mL), sat. NaHCO3 solution (30 mL x 2) and brine (40 mL). The organic layer was dried over Na2504, filtered and concentrated to dryness to afford a solid crude (2.5 g). Purification by typical silica gel flash chromatography using a Teledyne ISCO apparatus (Cy/TBME from 100:0 to 80:20) afforded thepure title compound (1.29 g, 48%), as a liquid. R= 2.36 mm. ?H NMR (CDC13): oe 7.40-7.28 (m,2H), 7.24-7.19 (m, 3H), 4.20-4.07 (m, 2H), 3.57 (td, 2H, J= 11.5, 2.5 Hz), 2.80 (tt, 1H, J= 11.5,4.2 Hz), 1.94-1.75 (m, 4H)., 1768-64-5
As the paragraph descriping shows that 1768-64-5 is playing an increasingly important role.
Reference£º
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA; PIOMELLI, Daniele; BANDIERA, Tiziano; BERTOZZI, Fabio; NUZZI, Andrea; FIASELLA, Annalisa; PONZANO, Stefano; PAGLIUCA, Chiara; REGGIANI, Angelo Mario; WO2014/144836; (2014); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics