Discovery of 2-(4-Bromobutoxy)tetrahydro-2H-pyran

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Preparation of para-terphenylylalkanethiols with different chain lengths

Terphenylylalkanethiols with different chain length were synthesized using palladium-catalyzed cross-coupling reactions. While the thiols with two and three methylene groups were obtained via photoaddition of thiopivalic acid to the respective alkenes, the longer terphenylylalkanethiols were synthesized by two consecutive Kumada cross-coupling reactions followed by a Mitsunobu reaction for the introduction of the sulfur functionality. Georg Thieme Verlag Stuttgart.

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Tetrahydropyran – Wikipedia,
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More research is needed about 31608-22-7

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Partially fluorinated liquid crystal material

The invention provides LC compositions that exhibit V-shaped switching when aligned in an analog device configuration and exhibit bistability when aligned in a bookshelf-type device configuration. The invention more specifically provides LC compositions of formula 1 and particularly chiral nonracemic compounds of formula 1 which exhibit bistable switching as well as V-shaped switching when aligned in appropriate device configurations. The invention also provides methods of using the compounds of the invention in making LC compositions and electooptical devices comprising an aligned layer of the compositions of this invention.

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The Absolute Best Science Experiment for 31608-22-7

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Synthesis of labelled terminal [14C]-acetylenes

There are several literature methods for conversion of 14C precursors into [14C]-acetylenes, and a number of these involve elaboration of [14C]-aldehydes into a terminal acetylenes. One method that involves mild conditions, and in our experience is high yielding and tolerant of a range of functional groups uses the Ohira-Bestmann reagent to effect this transformation. This document briefly describes some of the different methods that have been used for the preparation of [ 14C]-acetylenes and discusses two worked examples, the synthesis of [5-14C]-hex-5-ynoic acid and [benzene-(U)-14C]-7- methoxybenzofuran, both of which involve Ohira-Bestmann chemistry being used for the preparation of terminal [14C]-acetylenes. Copyright

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Tetrahydropyran – Wikipedia,
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Brief introduction of 2-(4-Bromobutoxy)tetrahydro-2H-pyran

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Racemic fluoro-substituted PGB2 analogs

This invention is racemic PGE2 alpha, racemic PGF2alpha, racemic PGF2 beta, racemic PGA2, racemic PGB2, analogs of those, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, abortion, and wound healing.

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Tetrahydropyran – Wikipedia,
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Extended knowledge of 2-(4-Bromobutoxy)tetrahydro-2H-pyran

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A molecular approach to self-assembly of trimethylsilylacetylene derivatives on gold

We recently discovered that a linear multifunctional trimethylsilylacetylene (TMSA) compound forms long-range and highly stable self-assembled monolayers (SAMs) on reconstructed Au(111). To better understand the interactions governing self-assembly in this new system, we synthesized a series of homologue organosilanes and performed scanning tunneling microscopy (STM) measurements at the Au(111)/n-tetradecane interface. The four TMSA-terminated linear silanes that we synthesized self-assemble in similar ways on gold, with the molecules standing upright on the surface. In contrast, compounds with a slightly modified terminal group but the same polyunsaturated linear chain above the TMSA head do not self-assemble. In particular, substituting a methyl group of TMSA with a more bulky one prevents self-assembly. Removing the C?C triple bond of TMSA or substituting the Si atom by a C atom also hinders self-assembly. Finally, substituting one methyl group of TMSA by a hydrogen atom induces self-assembly but in a different geometry. with the molecules lying flat on the gold surface in a quasi-epitaxy mode. Our molecular approach demonstrates the key role played by the TMSA head in self-assembly, its origin being twofold: 1) the TMSA layers are commensurate to the Au(111) adlattice along the (112) direction, and 2) the C?C triple bond of TMSA activates the Si atom and induces the creation of a surface Si-Au chemical bond. The highly stable TMSA-based SAMs appear then as promising materials for applications in surface modification.

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Tetrahydropyran – Wikipedia,
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14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates: Carboxylate modifications

The cytochrome P450 eicosanoid 14,15-epoxyeicosa-5,8,11-trienoic acid (14,15-EET) is a powerful endogenous autacoid that has been ascribed an impressive array of physiologic functions including regulation of blood pressure. Because 14,15-EET is chemically and metabolically labile, structurally related surrogates containing epoxide bioisosteres were introduced and have become useful in vitro pharmacologic tools but are not suitable for in vivo applications. A new generation of EET mimics incorporating modifications to the carboxylate were prepared and evaluated for vasorelaxation and inhibition of soluble epoxide hydrolase (sEH). Tetrazole 19 (ED50 0.18 muM) and oxadiazole-5-thione 25 (ED50 0.36 muM) were 12- and 6-fold more potent, respectively, than 14,15-EET as vasorelaxants; on the other hand, their ability to block sEH differed substantially, i.e., 11 vs >500 nM. These data will expedite the development of potent and specific in vivo drug candidates.

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Tetrahydropyran – Wikipedia,
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Discovery of 31608-22-7

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Synthesis of new potentially antiviral furan-fused compounds by thermolysis of benzocyclobutene derivatives

New potentially antiviral furan-fused tetracyclic compounds were prepared using intramolecular cycloaddition of o-quinodimethane generated by thermolysis of benzocyclobutene derivatives. It was found that the reaction course was changed depending on the length of alkyl chain connecting quinodimethane and furan ring.

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Dye, colored resin composition, a color filter, and an organic EL display device, a liquid crystal display device (by machine translation)

PROBLEM TO BE SOLVED: To provide a colored resin composition that obtains a color filter for satisfying both of heat resistance and solvent resistance, a color filter formed by using the colored resin composition, a high-quality liquid crystal display device and an organic EL display device.

SOLUTION: The dye contains a compound represented by formula (I), ZA+(wherein Zis a disulfonyl imide anion; A+is a cationic dye; at least any one of Zand A+has a crosslinkable group).

COPYRIGHT: (C)2013,JPO&INPIT

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Tetrahydropyran – Wikipedia,
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3-Substituted 2-Cyclopentenones from Cyclopentadienes

Oxidation of cyclopentadienes 1a-1j, which were prepared by alkylation of cyclopentadienyl anion with the corresponding alkyl bromides, with pyridinium chlorochromate (PCC) gave the 2-cyclopentenones 2a-2j respectively in 10-15percent yields.Reaction of 3 and 5 with PCC gave the spiro compounds 4 and 6 respectively in 75-80percent yields. Key Words 3-Substituted 2-cyclopentenones; Cyclopentadienes; PCC.

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Tosmic in the preparation of spiroacetals: Synthesis of pheromone components of olive fruit fly

The dialkylated tosylmethyl isocyanide derivatives obtained by alkylation of TosMIC with halohydrin derivatives, on hydrolysis lead to the formation of 1,7-dioxaspiroalkanes.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics