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Three naturally occurring compounds (Z)-6-heneicosen-11-one (1), (+/-)-(Z)-14-methyl-8-hexadecen-1-ol (2) and (+/-)-5,6-dehydrosenedigitalene (3) have been synthesised using lithium tetrachlorocuperate catalysed coupling reaction.

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Eight diversely substituted delta-allenic alcohols have been synthesized by using three different methods for the formation of the allenic linkage.When treated with silver nitrate or mercuric salts, these alcohols are transformed in fairly good yields into alpha-alkenyl-2 tetrahydropyrans.In addition to its regioselectivity in the formation of the heterocycle this reaction shows in certain cases a high stereoselectivity.Alcohols monosubstituted on the thermal allenic carbon lead to more than 90percent of the E product whereas the 2,4 or 2,6 disubstituted tetrahydropyrans are obtained in predominantly the Z configuration.

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Tetrahydropyran – Wikipedia,
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The first total synthesis for the novel fatty acid (±)-2-methoxy-6- icosynoic acid was accomplished in seven steps and in a 14% overall yield starting from 2-(4-bromobutoxy)-tetrahydro-2H-pyran. The title compound displayed an EC50 = 23 ± 1 muM against the human SH-SY5Y neuroblastoma cell line and an EC50 = 26 ± 1 muM against the human adenocarcinoma cervix cell line (HeLa) after 48 h of exposure. The corresponding non-methoxylated analog 6-icosynoic acid did not display cytotoxicity (EC50 > 500 muM) toward the studied cell lines as well as the 2-methoxyicosanoic acid (EC50 > 300 muM). The critical micelle concentration (CMC = 20-30 muM) for the (±)-2-methoxy-6-icosynoic acid was also determined. It was found that mu-methoxylation decreases the CMC of a fatty acid.

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Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. In homogeneous catalysis, catalysts are in the same phase as the reactants.31608-22-7, C9H17BrO2. A document type is Article, introducing its new discovery., SDS of cas: 31608-22-7

Plakoside A (1) {(2S,3R,11R*,12S*)-2-[(2? R,5? Z,11? R*, 12? S*)-2?-hydroxy-11?, 12?-methylene-5?-docosen-amido]-1-O-[2?-O- (3?-methyl-2?-butenyl)-beta-D-galactopyranosyl]-11,12- methylene-1,3-docosanediol} is a prenylated galactosphingolipid isolated as an immunosuppressant from the marine sponge Plakortis simplex. (2S,3R,11S,12R,2? R,5? Z,11? S,12? R)-Plakoside A (1) has been synthesized by combining the sphingosine part 16, the alpha-hydroxy acid part 28, and the prenylated sugar part 33. (2S,3R,11R,12S,2? R,5? Z,11? R,12? S)-Plakoside A (1?) has also been synthesized.

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Tetrahydropyran – Wikipedia,
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First synthesis of titled azamacrolides-minor components from Mexican bean beetle pupae secretions is described.

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An object of the present invention is to provide a drug having the inhibitory activity on ENPP2 which is a different target from that of the existing drug, as a medicament useful in a urinary excretion disorder patient for whom the existing drug has the insufficient effect. The present invention provides a compound represented by the general formula (I): (wherein definition of each group is as defined in the description) having the ENPP2 inhibitory activity, a salt thereof or a solvate thereof or a prodrug thereof, and an agent for preventing or treating urinary excretion disorder and/or improving symptoms thereof, containing them as an active ingredient.

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Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 31608-22-7, Name is 2-(4-Bromobutoxy)tetrahydro-2H-pyran, molecular formula is C9H17BrO2. In a Article,once mentioned of 31608-22-7, name: 2-(4-Bromobutoxy)tetrahydro-2H-pyran

Hydrogenation of methyl 7-hydroxyhept-5-ynoate followed by formation of the p-toluene-p-sulphonate ester and reaction with ethynylmagnesium bromide leads to an improved synthesis of methyl Z-non-5-en-8-ynoate, whose hexacarbonyldicobalt complex reacts smoothly with 2,5-dihydrofuran.Conventional “mixed cuprate” methodology is used to add the “beta”-side chain producing a novel, but biologically inactive bicyclic prostaglandin E2 analogue.Cobalt carbonyl complexed selectively with the terminal triple bond of a 1,3-diyne but the product proved unsuitable for similar synthetic elaboration.

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Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition. 31608-22-7, Name is 2-(4-Bromobutoxy)tetrahydro-2H-pyran, molecular formula is C9H17BrO2. In a Article,once mentioned of 31608-22-7, Formula: C9H17BrO2

Reaction of 3,4-dihydro-2H-pyran or 2-methoxytetrahydropyran with benzenesulphinic acid gave 2-benzenesulphonyl tetrahydropyran (1).Deprotonation of (1) followed by alkylation with carbonyl compounds or halides gave cyclic enol ether addition products by spontaneous elimination of benzenesulphinic acid.Interception of the initial addition products with aldehydes by reductive desulphonylation to give alkylated tetrahydropyran derivatives proceeded in moderate yield using sodium naphthalenide.Several of the cyclic enol ether addition products were further converted to spiroketals including syntheses of natural product pheromones from Dacus oleae and Paravespula vulgaris.

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The invention relates to compounds comprising an ester group for the detection in vivo of cells undergoing cell death (“dying cells”) such as, for example, cells undergoing apoptosis. These compounds are selectively retained in dying cells relative to normal cells. Thus, the compounds may be used in the detection, diagnosis and treatment of clinical conditions manifested by a cell death process.

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The alkylation of 1-alkynes in various solvents was investigated, and the optimum conditions for the production of acetylenic alcohols were obtained.

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