65412-03-5, 4-(2-Aminoethyl)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 63-(Phenylsulfonyl)-lambda/-[2-(tetrahydro-2H-pyran-4-yl)ethyl]-8-quinolinamine hydrochloride (E6)To 8-fluoro-3-(phenylsulfonyl)quinoline (D2) (300 mg), potassium carbonate (0.288 g: 2 eq) and 4-amino-ethyl[2-(tetrahydro-2H-pyran-4-yl)ethyl]amine (Apollo Scientific) (0.269 g, 2 eq) in DMSO(3 ml) were added to a 5 ml microwave vial. The mixture was heated at 18O0C under microwave irradiation for 1 hour. The reaction mixture was diluted with sodium hydrogen carbonate (20 ml) and extracted with ethyl acetate (3 x 20 ml). The ethyl acetate layers were combined and evaporated. The residue obtained was purified using the Flashmaster Il (gradient 10-80% ethyl acetate on 50 g silica column) to give the free base of the title compound (0.255 g).NMR (400MHz1 Chloroform-d6) delta 1.31-1.41 (2H1 m), 1.65-1.71 (5H, m), 3.33-3.49 (4H, m), 3.94-3.97 (2H, m), 6.93 (1 H, d), 7.22 (1 H1 d), 7.52-7.62 (4H1 m), 8.00-8.03(2H, m), 8.75 (1 H, d), 9.07 (1 H, d) EPO
As the paragraph descriping shows that 65412-03-5 is playing an increasingly important role.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/39220; (2007); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics